Results 261 to 270 of about 1,477,645 (352)

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

多発外傷に併発した呼吸不全に対してvenovenous extracorporeal membrane oxygenationを使用した5例の検討(Use of venovenous extracorporeal membrane oxygenation for multiple trauma patients with respiratory insufficiency: a five–case study) [PDF]

, 2016
岡田 一宏, 八木 貴典, 齋藤 伸行, 松本 尚, 横田 裕行, 別所 竜蔵, 畑 典武   +6 more
openalex   +1 more source

Distal weakness with respiratory insufficiency caused by the m.8344A > G “MERRF” mutation

Neuromuscular Disorders, 2014
E. Blakely, C. Alston, B. Lecky, B. Chakrabarti, G. Falkous, D. Turnbull, Robert W. Taylor, G. Gorman   +7 more
semanticscholar   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

[Diagnosis, classification and pathogenesis of respiratory insufficiency].

, 1978
Smirnov Ip
openalex   +1 more source

Risk factors and prognosis of critically ill cancer patients with postoperative acute respiratory insufficiency.

World Journal of Emergency Medicine, 2013
Xue-zhong Xing, Yong Gao, Hai-jun Wang, Quan-Hui Yang, Chu-lin Huang, S. Qu, Hao Zhang, Hao Wang, Qing-ling Xiao, K. Sun   +9 more
semanticscholar   +1 more source

Modification Strategies of Carbon‐Based Electrodes From Structural Regulation to Multifunctional Integration

Advanced Science, EarlyView.
Tracing the evolution from structural regulation to multifunctional integration, this paper systematically analyzes modification strategies for carbon‐based electrodes. It evaluates how element doping, surface functionalization, and composite material design affect the electrode performance, and offers perspectives on future applications and challenges
Yunlei Wang, Shitao Dou, Yifan Wu, Mingguang Wang, Taibin Wu   +4 more
wiley   +1 more source

Coagulation parameters and venous thromboembolism in patients with and without COVID-19 admitted to the Emergency Department for acute respiratory insufficiency. [PDF]

Thromb Res, 2020
Pizzi R, Gini G, Caiano L, Castelli B, Dotan N, Magni F, Virano A, Roveda A, Bertù L, Ageno W.   +9 more
europepmc   +1 more source

H⁺ Exchange‐Driven ppb‐Level and High‐Selective Formaldehyde Detection at Room Temperature for Environmental and Clinical Applications

Advanced Science, EarlyView.
This article presents an innovative room‐temperature formaldehyde sensor based on H⁺ exchange method, achieving ppb‐level detection limit and exceptional selectivity. The study highlights its practical potential for real‐time environmental monitoring and clinical diagnostic applications.
Lubing Cai, Mengyang Pang, Zhaosong Liu, Yanfei Li, Jiani Li, Zhaorui Zhang, Fengshuang Zheng, Chao Li, Ang Zheng, Xuemin Zhang   +9 more
wiley   +1 more source