Results 101 to 110 of about 1,605,382 (377)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Analysis of the Characteristics of Patients Presenting with Exacerbation of Asthma to Emergency Care Units [PDF]

, 2015
Background:Fatal asthma remains a serious problem, and patient self-management of asthma is important to prevent exacerbation. To reduce the asthma mortality rate, we analyzed the characteristics of patients who visited an emergency care unit with ...
Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Department Of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology Dokkyo Medical University, Hideyuki Satoh, Kentaro Nakano, Kumiya Sugiyama, Naruo Yoshida, Ryosuke Souma, Shingo Tokita, Takeshi Fukuda, Tomoshige Wakayama, Yasutsugu Fukushima   +17 more
core   +1 more source

Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome. [PDF]

, 2017
In the 50 years since acute respiratory distress syndrome (ARDS) was first described, substantial progress has been made in identifying the risk factors for and the pathogenic contributors to the syndrome and in characterising the protein expression ...
Calfee, Carolyn S, Meyer, Nuala J
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Paradoxical embolic stroke during catheter-directed thrombolytics in a patient with massive pulmonary embolism: A case report

Brain Circulation
Paradoxical embolism represents a critical and potentially fatal complication that can be associated with pulmonary embolism (PE). This case details a unique case of massive PE, further complicated by embolic stroke occurring during catheter-directed ...
Atefeh Ghorbanzadeh, Emily C Bendel, Damon E. Houghton   +2 more
doaj   +1 more source

The (human) respiratory rate at rest [PDF]

arXiv, 2022
All schoolchildren know how often they breathe, but even experts don't know exactly why. The aim of this publication is to develop a model of the resting spontaneous breathing rate using physiological, physical and mathematical methods with the aid of the principle that evolution pushes physiology in a direction that is as economical as possible.
arxiv  

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

A Semi-Markov Chain Approach to Modeling Respiratory Patterns Prior to Extubation in Preterm Infants [PDF]

arXiv, 2018
After birth, extremely preterm infants often require specialized respiratory management in the form of invasive mechanical ventilation (IMV). Protracted IMV is associated with detrimental outcomes and morbidities. Premature extubation, on the other hand, would necessitate reintubation which is risky, technically challenging and could further lead to ...
arxiv  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

EMPADE Study: Evaluation of Medical Prescriptions and Adverse Drug Events in COPD Patients Admitted to Intensive Care Unit [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: Inappropriate drug usage may preclude ideal benefit due to increased medical cost, antimicrobial resistance, adverse effects and mortality.
Mir S. Adil, M. Amer Khan, M. Nematullah Khan, Ihtisham Sultan, M. Aamer Khan, S. Amir Ali, Afroze Farooqui   +6 more
doaj   +1 more source