Results 41 to 50 of about 1,814,974 (307)

Classification of Respiratory Diseases

Current Directions in Biomedical Engineering
Contactless measurement methods offer a novel approach to assessing respiratory parameters. This study investigates the feasibility of classifying chronic obstructive pulmonary disease, asthma, and healthy individuals using depth-based plethysmography ...
Wichum Felix, Wiede Christian, Seidl Karsten   +2 more
doaj   +1 more source

White lung with milky effusion

Clinical Case Reports, 2020
Thoracic duct injury is a rare complication of dorsal spine operations. Ultrasound chest plays an important tool for rapid diagnosis of acute dyspnea, drainage of massive effusion, and daily follow‐up. Conservative treatment of postoperative chylous with
Tamer Mohamed Zaalouk, Zouheir Ibrahim Bitar, Ossama Sajeh Maadarani, ALAsmar Mohammed El‐shably   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Chest drainage, a basic but essential procedure

Respirology Case Reports
Key message Chest drainage is a basic and important procedure in the treatment of pneumothorax. When properly implemented, even the most severely ill patients may be able to be treated without surgical intervention.
Masamitsu Hamakawa, Tadashi Ishida
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A pilot study of the serum telomerase activity in non-small cell lung cancer (NSCLC) [PDF]

, 2000
Session - Respiratory & Critical Care Medicine: no.
Ho, JCM, Lam, WK, Leung, R, Tsang, KWT, Zheng, L   +4 more
core   +1 more source

Spontaneous pneumomediastinum and pneumopericardium in a young healthy adult with plans for air travel

Clinical Case Reports, 2020
Although rare, pneumomediastinum and pneumopericardium should be considered in patients presenting with sudden onset post‐tussive chest discomfort.
Joseph Winterton, Simon Biart
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Tailoring NIV by dynamic laryngoscopy in a child with spinal muscular atrophy type I

Clinical Case Reports, 2021
Dynamic laryngoscopy during noninvasive (NIV) respiratory therapy is feasible and may facilitate optimal and individualized treatment in patients with chronic respiratory failure, also in children.
Maria Vollsæter, Anett Skjoldmo, Ola Røksund, Magnus Hilland, Tiina Andersen   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source