Results 71 to 80 of about 1,793,959 (342)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Up-regulation of circulating adhesion molecules in stable bronchiectasis [PDF]

, 2000
Session - Respiratory & Critical Care Medicine: no.
Ho, JC, Ip, MSM, Lam, WK, Leung, RH, Ooi, CGC, Shum, IH, Tipoe, GL, Tsang, KWT, Zheng, L   +8 more
core  

Sarcoidosis Presenting as Acute Respiratory Distress Syndrome. [PDF]

, 2018
Sarcoidosis is a multisystem granulomatous disease of unknown origin. It typically involves the lungs and mediastinal lymph nodes in a chronic fashion. However, acute syndrome has been reported possibly in response to systemic release of proinflammatory ...
Chan, Vincent, Lashari, Bilal, Raza, Ahmad, Ward, William   +3 more
core   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Intranasal Dexmedetomidine Administration Precipitates Respiratory Failure in Child With Croup and Asthma

Clinical Case Reports
Intranasal dexmedetomidine administration in clinically recommended doses has a small but important risk of causing catastrophic respiratory failure in the setting of preexisting severe respiratory workloads.
William E. Novotny, Pam Fox, Dynita Haislip   +2 more
doaj   +1 more source

The Importance of Chest CT Scan in COVID-19

Acta Medica Indonesiana, 2020
The coronavirus disease 2019 (COVID-19) is a highly transmissible acute respiratory disease that is caused by the Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2), a beta coronavirus first discovered in Wuhan, China, in late 2019.
Eric Daniel Tenda, Mira Yulianti, Moses Mazmur Asaf, Reyhan Eddy Yunus, Wita Septiyanti, Vally Wulani, Ceva Wicaksono Pitoyo, Cleopas Martin Rumende, Siti Setiati   +8 more
doaj  

Digest of Russian Space Life Sciences, issue 33 [PDF]

This is the thirty-third issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 55 papers published in Russian journals. The abstracts in this issue have been identified as relevant to the following areas of space biology and medicine:
Rowe, Joseph, Stone, Lydia Razran, Teeter, Ronald   +2 more
core   +1 more source

Nitric oxide (NO) levels in exhaled air, sputum, serum, saliva, and urine of bronchiectasis subjects: a comparision study [PDF]

, 2000
Session - Respiratory & Critical Care Medicine: no.
Chan, S, Fung, PCW, Ho, JCM, Ip, S, Lam, WK, Leung, RYH, Shum, IHY, Tsang, KWT, Wang, J, Zheng, L   +9 more
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Metastatic Mediastinal Germ Cell Tumour: A Florid and Fulminant Presentation

Respirology Case Reports
A previously healthy teenager presented with acute respiratory distress and constitutional symptoms. Imaging revealed a mediastinal mass with multiple pulmonary nodules, and markedly elevated β‐HCG confirmed metastatic choriocarcinoma.
Zhong Xhen Khor
doaj   +1 more source