Results 101 to 110 of about 144,351 (212)

A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3‐WG1C: Phenotyping working group of the ILAE/AES joint translational task force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events.
Melissa Barker‐Haliski, Julika Pitsch, Aristea S. Galanopoulou, Rüdiger Köhling   +3 more
wiley   +1 more source

Parameter identifiability of a respiratory mechanics model in an idealized preterm infant [PDF]

arXiv, 2018
The complexity of mathematical models describing respiratory mechanics has grown in recent years to integrate with cardiovascular models and incorporate nonlinear dynamics. However, additional model complexity has rarely been studied in the context of patient-specific observable data.
arxiv  

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

An Efficient Heat and Peroxynitrite Generating Nanoplatform for Multimodal Imaging‐guided Precision Tumor Phototherapy

Aggregate, EarlyView.
Reported herein is the rational‐designed aggregation‐induced emission molecule (BPT), its nanoparticles (BPT NPs), and further processed heat and peroxynitrite generating nanoplatform for precision multimodal imaging‐guided tumor phototherapy. This nanoplatform showed near‐infrared II fluorescence, photothermal, and photoacoustic imaging capabilities ...
Ziyi Xu, Mingkun Lv, Jingkai Yang, Tingting Li, Jiahui Lv, Jiaxin Li, Hongjun Xiao, Yicheng Yang, Siyu Zhou, Xuan Tan, Li Cheng, Heng Guo, Lei Xi, Pan‐Lin Shao, Bo Zhang   +14 more
wiley   +1 more source

A Shared Control Method of Multiobjective Motion Fusion for Surgical Robot

Advanced Intelligent Systems, EarlyView.
This paper proposes an innovative shared control method that can handle multiple objectives task by integrating various types of controllers. It not only takes into account the priorities among the objectives but also allows for the flexible addition or removal of objective controllers.
Xilin Xiao, Xiaojian Li, Hangjie Mo, Yudong Shi, Jing Fang, Ling Li, Bo Ouyang, Shanlin Yang   +7 more
wiley   +1 more source

Reconstructing physiological signals from fMRI across the adult lifespan [PDF]

arXiv
Interactions between the brain and body are of fundamental importance for human behavior and health. Functional magnetic resonance imaging (fMRI) captures whole-brain activity noninvasively, and modeling how fMRI signals interact with physiological dynamics of the body can provide new insight into brain function and offer potential biomarkers of ...
arxiv  

Personalized Kirigami Strain Sensors for in vivo Applications

Advanced Intelligent Systems, EarlyView.
Rapid prototyping of strain sensors is demonstrated using a laser cutter that both converts carbon‐based material to strain responsible graphene and generates cuts in a kirigami‐style pattern that allows enhanced substrate flexibility. This method is used to generate wearable sensors for monitoring heart rate, limb/finger motion, and abdominal ...
Siheng Sean You, Max Schober, Soufyane Ben‐Ayed, Sahab Babaee, Stephanie Owyang, Josh Jenkins, Peter R. Chai, Giovanni Traverso   +7 more
wiley   +1 more source

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection

Animal Models and Experimental Medicine, EarlyView.
This review explores the potential mechanisms, complications, risk factors, and future research directions related to osteoporosis secondary to SARS‐CoV‐2 infection. Key mechanisms include an imbalance between osteoclast and osteoblast activity driven by direct viral effects on bone, inflammation, hypoxia, dysregulation of noncoding RNAs, and metabolic
Jinlong Wang, Yibai Xiong, Zhiqi Song, Yanhong Li, Ling Zhang, Chuan Qin   +5 more
wiley   +1 more source

Tongxinluo enhances the effect of atorvastatin on the treatment of atherosclerosis with chronic obstructive pulmonary disease by maintaining the pulmonary microvascular barrier

Food Science &Nutrition, Volume 11, Issue 1, Page 390-407, January 2023., 2023
COPD aggravates AS, possibly through the destruction of pulmonary microvascular barrier function; thus, lung inflammation triggers systemic inflammation. In treating COPD with AS, TXL enhances the antiatherosclerotic effect of Ato, protecting the pulmonary microvascular barrier.
Xiangnan Kuang, Yafen Wang, Shiqiao Liu, Liping Chang, Yujie Yin, Zhen Li, Yi Liu, Wenyan Li, Yunlong Hou, Hongtao Wang, Junqing Liang, Zhenhua Jia   +11 more
wiley   +1 more source