Results 41 to 50 of about 385,836 (215)

Bagasse dust exposure and chronic respiratory symptoms among workers in the Metehara and Wonji sugar factories in Ethiopia: a longitudinal study design

BMJ Open Respiratory Research, 2023
Background Ethiopia’s sugar factories are growing by creating job opportunities for thousands of workers with varying educational, professional and socioeconomic backgrounds.
Gabriel Okello, Muluken Azage, Mitiku Debela, Negussie Deyessa Kebeta, Achenef Motbainor Begosaw   +4 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Evaluating the fit and performance of flat-fold, cup, and three-panel respirators among Thai healthcare personnel

Frontiers in Public Health
IntroductionHealthcare personnel (HCP) face high risks of airborne infections, including coronavirus disease 2019 (COVID-19), tuberculosis, and measles.
Kampanat Wangsan, Kampanat Wangsan, Ratana Sapbamrer, Ratana Sapbamrer, Wachiranun Sirikul, Wachiranun Sirikul, Wuttipat Kiratipaisarl, Krongporn Ongprasert, Pheerasak Assavanopakun, Pheerasak Assavanopakun, Vithawat Surawattanasakul, Vithawat Surawattanasakul, Amornphat Kitro, Amornphat Kitro, Jinjuta Panumasvivat, Jinjuta Panumasvivat, Amnart Wongcharoen   +16 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A full-face mask for protection against respiratory infections

BioMedical Engineering OnLine, 2022
Background Aerosols and droplets are the transmission routes of many respiratory infectious diseases. The COVID-19 management guidance recommends against the use of nebulized inhalation therapy directly in the emergency room or in an ambulance to prevent
Chen-Hsun Weng, Chia-Lung Kao, Po-Wei Chiu, Shao-Peng Huang, Yuh-Shin Kuo, Yu-Yuan Lin, I-Chen Lin, Hung-Chieh Chang, Chien-Hsin Lu, Chih-Hao Lin   +9 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Non-specific Effect of Vaccines: Immediate Protection against Respiratory Syncytial Virus Infection by a Live Attenuated Influenza Vaccine

Frontiers in Microbiology, 2018
The non-specific effects (NSEs) of vaccines have been discussed for their potential long-term beneficial effects beyond direct protection against a specific pathogen.
Young J. Lee, Jeong Y. Lee, Yo H. Jang, Sang-Uk Seo, Jun Chang, Jun Chang, Baik L. Seong, Baik L. Seong   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source