Results 171 to 180 of about 45,149 (247)

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Assessment of respiratory function status among commercial motorcycle drivers in Sawla town, southern Ethiopia: comparative cross-sectional study. [PDF]

Sci Rep
Banti R, Kofole Z, Kanko T.
europepmc   +1 more source

Advances in vital‐sign prediction and early‐warning models for underground coal mine workers integrating environmental factors

Deep Underground Science and Engineering, EarlyView.
This review synthesizes advances in predicting miners' vital signs by integrating environmental monitoring (dust, temperature, and gas) with physiological data. It highlights multi‐source data fusion techniques and early‐warning models for enhanced occupational safety in underground coal mines.
Junji Zhu, Dawei Cui, Yingjie Liu, Yuntao Liang, Yue Zhang   +4 more
wiley   +1 more source

Reusing depleted oil and gas wells for geothermal energy: Feasibility, challenges, and a decision‐making framework for sustainable conversion

Deep Underground Science and Engineering, EarlyView.
The graphical abstract presents a structured decision‐support framework for assessing the feasibility of converting depleted oil and gas wells into geothermal energy systems. The left panel illustrates a comprehensive, multi‐stage decision‐making framework progressing from prefeasibility screening and technical–economic analysis to policy alignment ...
Karolina Bieryt, Yu Pan, Heinz Konietzky, Fei Wang   +3 more
wiley   +1 more source

Insights into the mechanisms of infection transmission via inanimate surfaces. [PDF]

Front Microbiol
Iskandar K, Marchin L, Roques C.
europepmc   +1 more source

Water Electrolysis Technologies for Extraterrestrial Water Resource Conversion

EcoEnergy, EarlyView.
This paper reviews four water electrolysis technologies for extraterrestrial water conversion: alkaline water electrolysis, proton exchange membrane water electrolysis, solid oxide water electrolysis, and anion exchange membrane water electrolysis. It elaborates on their mechanisms, components, and integration, highlighting challenges such as water ...
Yawen Jiang, Yuan Zhao, Lin Zu, Lili Ling, Yongwei Zhao, Jun Di, Pin Song   +6 more
wiley   +1 more source

Gaps and Future Directions in the Research About Masking and Voice Production: Bibliometric Analysis, Systematic Literature Review, and Meta-analysis. [PDF]

J Voice
Cantor-Cutiva LC, Ramirez Ardila MDP, Hunter EJ.   +2 more
europepmc   +1 more source

Toward a Paradigm Shift in Low‐Temperature SCR Catalyst Design: Defect Engineering and Data‐Driven Integration

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work systematically reviews the key factors influencing the performance of low‐temperature NH3‐SCR. The mechanism and challenges of defect engineering strategies, such as oxygen vacancies, heteroatom doping, crystal facet exposure, and surface reconstruction, in controlling both activity and selectivity were analyzed.
Rongrong Kan, Pinjing He, Fan Lü, Hua Zhang   +3 more
wiley   +1 more source

Nuances of perioperative lung isolation and airway management. [PDF]

J Thorac Dis
Pasch STM, Pravder HD.
europepmc   +1 more source

Lignocellulosic Triboelectric Materials for Energy Harvesting and Emerging Applications: A Review on Lignin‐Molecular Engineering toward Improved Performance

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Contrasting sustainable biomass with depleting petroleum resources, this review charts the evolutionary timeline of lignin‐based TENGs. We systematically evaluate their fundamental mechanisms, enhancement strategies, and applications in green self‐powered electronics.
Yuxin Yang, Boyu Du, Yuwen Wang, Tian Tang, Yuxuan Xie, Jiajun Zhang, Yajun Zhang, Jingyu Xu, Xing Wang, Chuanyin Xiong   +9 more
wiley   +1 more source