Results 151 to 160 of about 152,217 (292)

Respiratory syncytial virus glycoproteins uptake occurs through clathrin-mediated endocytosis in a human epithelial cell line

Virology Journal, 2008
Cell-surface viral proteins most frequently enter the cell through clathrin or caveolae endocytosis. Respiratory syncytial virus antigen internalization by immune cells is via caveolin, however, uptake of paramyxovirus cell membrane proteins by non ...
Gómez-García Beatriz, Sánchez-Hernández Carla, Gutiérrez-Ortega Abel   +2 more
doaj   +1 more source

Ferrets as a Novel Animal Model for Studying Human Respiratory Syncytial Virus Infections in Immunocompetent and Immunocompromised Hosts

Viruses, 2016
Human respiratory syncytial virus (HRSV) is an important cause of severe respiratory tract disease in immunocompromised patients. Animal models are indispensable for evaluating novel intervention strategies in this complex patient population.
K. Stittelaar, L. D. de Waal, G. van Amerongen, E. Veldhuis Kroeze, P. Fraaij, C. V. van Baalen, J. V. van Kampen, E. van der Vries, A. Osterhaus, R. D. de Swart   +9 more
semanticscholar   +1 more source

Validation of the Scale for the Assessment of Illness Behavior (SAIB) in a community sample of elderly people.

, 2012
The aim of this study was to evaluate the construct validity of the SAIB in a community sample of elderly people. The SAIB was administered to a large community sample representative of the German population aged 60-85 years (n=1593).
Bhaskaran, K, Brähler, E, Engelberg, PM, Glaesmer, H, Singer, S   +4 more
core   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, EarlyView.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Virus isolation and genotype identification of human respiratory syncytial virus in Guizhou Province, China

Brazilian Journal of Infectious Diseases, 2019
To investigate the genetic variation and molecular epidemiology characteristics of Human Respiratory Syncytial Virus (HRSV) in Guizhou Province, nasopharyngeal aspirates were collected from patients with acute respiratory infection (ARI) in Guizhou ...
Ting Zhao, Zhixu Ye, Binlin Wang, Yuxia Cui, Yingjie Nie, Bin Yang, Kun Chen, Hua Zhang, Fangfang Hu, Fuxun Yu   +9 more
doaj   +1 more source

Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication

Scientific Reports, 2016
Human respiratory syncytial virus (hRSV) is a leading cause of acute lower respiratory tract infection in infants, elderly and immunocompromised individuals. To date, no specific antiviral drug is available to treat or prevent this disease.
B. Bailly, B. Bailly, B. Bailly, Charles-Adrien Richard, Geeta Sharma, Lingqing Wang, L. Johansen, J. Cao, J. Cao, Vishal Pendharkar, Danilal Champalal Sharma, M. Galloux, Yuzheng Wang, R. Cui, Gen Zou, Patrice Guillon, M. Itzstein, J. Éléouët, R. Altmeyer   +18 more
semanticscholar   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Influenza A virus interferes with respiratory syncytial virus in mice and reconstituted human airway epithelium

Microbiology Spectrum
Epidemiological studies suggest that respiratory syncytial virus (RSV) and influenza A virus (IAV) might interfere with each other. Viral interference mainly relies on interferon production elicited by a first virus that reduces the replication of a ...
Shella Gilbert-Girard, Jocelyne Piret, Chantal Rhéaume, Julie Carbonneau, Nathalie Goyette, Christian Couture, Guy Boivin   +6 more
doaj   +1 more source

Emerging Roles of Heparanase in Viral Pathogenesis

Pathogens, 2017
Heparan sulfate (HS) is ubiquitously expressed on mammalian cells. It is a polysaccharide that binds growth factors, cytokines, and chemokines, and thereby controls several important physiological functions.
Neel Thakkar, Tejabhiram Yadavalli, Dinesh Jaishankar, Deepak Shukla   +3 more
doaj   +1 more source

Risk and protective factors for meningococcal disease in adolescents: matched cohort study [PDF]

, 2006
Objective: To examine biological and social risk factors for meningococcal disease in adolescents. Design: Prospective, population based, matched cohort study with controls matched for age and sex in 1:1 matching.
Booth, C., Booy, R., Coen, P.G., Kaczmarski, E., Klein, N., Peckham, C., Stuart, J.M., Tully, J., Viner, R.M., Zambon, M.   +9 more
core