Results 71 to 80 of about 79,643 (236)

SARS and Common Viral Infections

Emerging Infectious Diseases, 2004
In California, molecular testing was useful in decreasing suspicion for severe acute respiratory syndrome (SARS), by detecting common respiratory pathogens (influenza A/B, human metapneumovirus, picornavirus, Mycoplasma pneumoniae, Chlamydia spp ...
Janice K. Louie, Jill K. Hacker, Jennifer Mark, Shilpa S. Gavali, Shigeo Yagi, Alex Espinosa, David P. Schnurr, Cynthia K. Cossen, Erin R. Isaacson, Carol A. Glaser, Marc Fischer, Arthur L. Reingold, Duc J. Vugia   +12 more
doaj   +1 more source

Conformational Isomerization Involving Conserved Proline Residues Modulates Oligomerization of the NS1 Interferon Response Inhibitor from the Syncytial Respiratory Virus [PDF]

, 2019
Interferon response suppression by the respiratory syncytial virus relies on two unique nonstructural proteins, NS1 and NS2, that interact with cellular partners through high-order complexes.
Alonso, Leonardo Gabriel, Aran, Martin, Borkosky, Silvina Susana, Conci, Julieta, de Oliveira, Guilherme A. P., de Prat Gay, Gonzalo, Esperante, Sebastian, Mohana Borges, Ronaldo, Pagani, Talita Duarte, Álvarez Paggi, Damián Jorge   +9 more
core   +1 more source

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

Advanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz, Lukas Wettstein, Armando Rodríguez Alfonso, Rayhane Nchioua, Pascal von Maltitz, Dan Pascal Jean Albers, Fabian Zech, Julie Vandeput, Lieve Naesens, Giorgio Fois, Veronika Neubauer, Nico Preising, Emilia Schmierer, Yasser Almeida‐Hernandez, Moritz Petersen, Ludger Ständker, Sebastian Wiese, Peter Braubach, Manfred Frick, Eberhard Barth, Daniel Sauter, Frank Kirchhoff, Elsa Sanchez‐Garcia, Annelies Stevaert, Jan Münch   +24 more
wiley   +1 more source

Occurrence of human respiratory syncytial virus in summer in Japan [PDF]

Epidemiology and Infection, 2016
SUMMARYIn temperate zones, human respiratory syncytial virus (HRSV) outbreaks typically occur in cold weather, i.e. in late autumn and winter. However, recent outbreaks in Japan have tended to start during summer and autumn. This study examined associations of meteorological conditions with the numbers of HRSV cases reported in summer in Japan.
Akinobu Hibino, T. Takeuchi, Yugo Shobugawa, Reiko Saito, Ren Yagami, Hiroki Kondo, Takashi Odagiri, Mohd Rohaizat Hassan   +7 more
openaire   +3 more sources

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel, Julie McLaughlin, Marta Frigeni   +2 more
wiley   +1 more source

Prevalence of rhinovirus in wheezing children: a comparison with respiratory syncytial virus wheezing

Brazilian Journal of Infectious Diseases, 2016
Objective: To explore the distribution and clinical manifestations of rhinovirus infection in wheezing children, and compare the clinical differences between rhinovirus- and respiratory syncytial virus-induced wheezing.
Huiquan Sun, Qiufeng Sun, Wunjun Jiang, Zhengrong Chen, Li Huang, Meijuan Wang, Wei Ji, Xuejun Shao, Yongdong Yan   +8 more
doaj  

The Use of Aerosolized Ribavirin in Respiratory Syncytial Virus Lower Respiratory Tract Infections in Adult Immunocompromised Patients: A Systematic Review [PDF]

, 2019
Introduction: Respiratory syncytial virus (RSV)–associated lower respiratory tract infection (LRTI) is a concern in immunocompromised patients. Aerosolized ribavirin (RBV AER) is used for treatment of RSV LRTI; however, adverse events and rising drug ...
Avery, Lisa M., Hoffmann, Charles, Whalen, Karen M.   +2 more
core   +2 more sources

Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges

Animal Models and Experimental Medicine, EarlyView.
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley   +1 more source

A Single-Center Study of Viral Respiratory Tract Infections in Hospitalized Children From the Kurdistan Region of Iraq

Global Pediatric Health, 2018
Viral respiratory infections are among the most common causes of disease in humans, particularly in young children, and remain a major public health problem worldwide.
Dlshad A. Hassan PhD, Shwan K. Rachid PhD, John Ziebuhr MD   +2 more
doaj   +1 more source

Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland [PDF]

, 2018
While acute respiratory tract infections can trigger cardiovascular events, the differential effect of specific organisms is unknown. This is important to guide vaccine policy.Using national infection surveillance data linked to the Scottish Morbidity ...
Andrew C. Hayward, Charlotte Warren-Gash, Heather Whitaker, Huijskens, Hung, Jim McMenamin, Ren, Reyes, Ruth Blackburn, Wen   +9 more
core   +3 more sources