Results 91 to 100 of about 40,857 (208)
Respiratory syncytial virus (RSV) is known to be one of the main causes of respiratory infections, which, in rare cases, can lead to neurological complications, including encephalitis, encephalopathy, and seizure.
Chi-Man Kuok +2 more
doaj +1 more source
A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Tobias Alfvén, Tania Reza, Alieu Sowe
wiley +1 more source
ABSTRACT Aim This mini review describes the history of infant respiratory syncytial virus (RSV) immunoprophylaxis and the latest advances in this area. It also reviews the efficacy, safety and impact of the recently introduced prophylactic strategies. Method This narrative review is based on a targeted review of published literature, with emphasis on ...
Santtu Heinonen, Pekka Vartiainen
wiley +1 more source
Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID‐19 Pandemic
ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Matti Sällberg
wiley +1 more source
Advances in Cytosolic dsRNA Sensing of Viral Infections
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley +1 more source
RSV Disease Among Hospitalized Children: Second vs. First Year of Life Multicenter Study
ABSTRACT Background Respiratory syncytial virus (RSV) is a leading cause of pediatric hospitalization, yet data on children hospitalized with RSV in their second year of life are limited. Objective To compare clinical characteristics and management practices of children hospitalized with RSV during their second versus first year of life.
Keren Armoni Domany +17 more
wiley +1 more source
ABSTRACTBackgroundIn Australia, non‐pharmaceutical interventions introduced early in 2020 to curtail the spread of COVID‐19 resulted in the temporary elimination of influenza. We used data from this influenza‐free period (2021) to validate influenza mortality burden predictions from time‐series models.MethodsTime‐series models were parameterised with ...
Jessie J. Goldsmith +4 more
wiley +1 more source
Cytokine Profile Changes in Infants With Respiratory Syncytial Virus Bronchiolitis With Nirsevimab
Pediatric Pulmonology, Volume 61, Issue 11, November 2026.
José Antonio Cañas +9 more
wiley +1 more source
Outcomes After Respiratory Virus Detection Prior to Pediatric Solid Organ Transplantation
ABSTRACT Background Respiratory viral infections are associated with increased pulmonary morbidity in immunocompromised populations. It is not known whether pediatric solid organ transplant (SOT) recipients who test positive for respiratory viruses prior to transplant have increased risk of adverse pulmonary outcomes.
Mallory Go +4 more
wiley +1 more source
From Dysbiosis to Disease: How Vaginal Microbiota Shape Group B Streptococcus Pathogenesis
Lactobacillus crispatus plays a critical role in the vaginal microbiome. Limiting glucose shifts metabolism toward HMO consumption and amino acid metabolism. These actions enable alkali production and competition. Homeostasis, characterized by dense Lactobacilli colonization and suppression of pathogens, provides resistance to dysbiosis.
Julie A. Talbert, Steven D. Townsend
wiley +1 more source

