Results 31 to 40 of about 1,222,404 (290)

КЛИНИКО-ФУНКЦИОНАЛЬНЫЕ СОСТАВЛЯЮЩИЕ БРОНХОЛЕГОЧНОГО СИНДРОМА ПРИ ДИСПЛАЗИИ СОЕДИНИТЕЛЬНОЙ ТКАНИ

Архивъ внутренней медицины, 2015
To study the respiratory symptomatology in patients with connective tissue dysplasia (CTD) were surveyed 305 young people. Clinical and functional components of bronchopulmonary syndrome in CTD were identified through a comprehensive examination ...
М. В. Вершинина, Г. И. Нечаева, Л. М. Гринберг, С. Е. Говорова, А. А. Хоменя, Н. В. Багишева   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Association between preoperative oxygen reserve index and postoperative pulmonary complications: a prospective observational study [PDF]

Korean Journal of Anesthesiology
Background The oxygen reserve index (ORi) noninvasively measures oxygen levels within the mild hyperoxia range. To evaluate whether a degree of increase in the ORi during preoxygenation for general anesthesia is associated with the occurrence of ...
Sangho Lee, Halin Hong, Hyojin Cho, Sang-Wook Lee, Ann Hee You, Hee Yong Kang, Sung Wook Park, Mi Kyeong Kim, Jeong-Hyun Choi   +8 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Detection and molecular characterization of mastadenoviruses in calves with respiratory system infection [PDF]

Eurasian Journal of Veterinary Sciences, 2022
Aim: Bovine adenovirus (BAdV) is one of the viral agents that causes respiratory illness in cattle, along with numerous other viral agents. Although the prevalence of BAdV has been determined by serological studies conducted in our country, there are ...
İlke Karayel Hacıoğlu, Selda Duran Yelken, Feray Alkan   +2 more
doaj  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Mapping the intersection of demographics, behavior, and government response to the COVID-19 pandemic: an observational cohort study

BMC Global and Public Health
Background During the early phase of the COVID-19 pandemic, the province of Ontario enacted restrictions and recommendations that changed over time. These measures were effective in reducing COVID-19-related illness and deaths, but adherence to these non-
Katherine M. Kennedy, Erica N. DeJong, Alexander W.Y. Chan, Allison E. Kennedy, Alainna Jamal, Michael G. Surette, Maggie J. Larché, Mark Larché, Nathan Hambly, Kjetil Ask, Stephanie A. Atkinson, Paul D. McNicholas, Allison McGeer, Brenda L. Coleman, Dawn M.E Bowdish   +14 more
doaj   +1 more source

Clinical characteristics of amyloidosis with isolated respiratory system involvement: A review of 13 cases

Annals of Thoracic Medicine, 2012
Background: Isolated pulmonary amyloidosis is a very rare disease. Methods: We retrospectively reviewed the records of patients with pathologically proven isolated pulmonary amyloidosis treated at our hospital from 1990 to 2011. Results: There were 9
Haiqing Chu, Lan Zhao, Zhemin Zhang, Tao Gui, Xianghua Yi, Xiwen Sun   +5 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source