Characterization of the viral microbiome in patients with severe lower respiratory tract infections, using metagenomic sequencing. [PDF]
PLoS ONE, 2012 The human respiratory tract is heavily exposed to microorganisms. Viral respiratory tract pathogens, like RSV, influenza and rhinoviruses cause major morbidity and mortality from respiratory tract disease.
Fredrik Lysholm +9 more
doaj +6 more sources
Mycobacteriophages in diagnosis and alternative treatment of mycobacterial infections
Frontiers in Microbiology, 2023 Antimicrobial resistance is an increasing threat to human populations. The emergence of multidrug-resistant “superbugs” in mycobacterial infections has further complicated the processes of curing patients, thereby resulting in high morbidity and ...
Xudong Ouyang +14 more
doaj +1 more source
Enhancing TB Vaccine Efficacy: Current Progress on Vaccines, Adjuvants and Immunization Strategies
Vaccines, 2023 Tuberculosis (TB) remains a global infectious disease primarily transmitted via respiratory tract infection. Presently, vaccination stands as the primary method for TB prevention, predominantly reliant on the Bacillus Calmette–Guérin (BCG) vaccine ...
Hui Wang +6 more
doaj +1 more source
Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge
Frontiers in Immunology, 2021 Evidence supports a role of complement anaphylatoxin C5a in the pathophysiology of COVID-19. However, information about the evolution and impact of C5a levels after hospital discharge is lacking. We analyzed the association between circulating C5a levels
Yaiza Senent +35 more
doaj +1 more source
Elevated microRNA-21 Is a Brake of Inflammation Involved in the Development of Nasal Polyps
Frontiers in Immunology, 2021 BackgroundCRSwNP is an inflammatory disease but the mechanism is not yet fully understood. MiR-21, a member of miRNAs, has been reported to play roles in mediating inflammation.
Ruowu Liu +11 more
doaj +1 more source
Serum β2-microglobulin may be a viral biomarker by analyzing children with upper respiratory tract infections and exanthem subitum: a retrospective study [PDF]
PeerJ, 2021 Background Due to the lack of effective and feasible viral biomarkers to distinguish viral infection from bacterial infection, children often receive unnecessary antibiotic treatment.
Xulong Cai +4 more
doaj +2 more sources
Decoding the Distribution of Glycan Receptors for Human-Adapted Influenza A Viruses in Ferret Respiratory Tract [PDF]
, 2011 Ferrets are widely used as animal models for studying influenza A viral pathogenesis and transmissibility. Human-adapted influenza A viruses primarily target the upper respiratory tract in humans (infection of the lower respiratory tract is observed less
Aarthi Chandrasekaran +6 more
core +13 more sources
An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection [PDF]
, 2020 beta-Defensins protect the respiratory tract against the myriad of microbial pathogens entering the airways with each breath. However, this potentially hostile environment is known to serve as a portal of entry for herpesviruses.
Boyen, Filip +8 more
core +2 more sources
, 2012 Cytological investigation of the pulmonary tract is one of the most useful diagnostic tests available to the clinician. A wide range of samples can be provided to the laboratory from a variety of sampling techniques. In many cases, the cytologist can provide a clear diagnosis of malignancy, infection, or other specific disease.
Michael Sheaff, Naveena Singh
openaire +2 more sources