Results 101 to 110 of about 346,283 (289)

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielman, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

Treatment of bacterial respiratory infections

South African Family Practice, 2019
Acute respiratory tract infections are one of the most common reasons that result in general practitioner consultations. Viruses are the most common cause of both upper- and lower respiratory tract infections, however pneumonia is usually bacterial in ...
A. D. van Eyk
doaj   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses [PDF]

, 2011
Background Methylene diphenyl diisocyanate (MDI), a reactive chemical used for commercial polyurethane production, is a well-recognized cause of occupational asthma.
Herrick, Christina A, Liu, Jian, Redlich, Carrie A, Robinson, Eve, Wisnewski, Adam V, Xu, Lan   +5 more
core   +3 more sources

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Family doctors' attitudes towards patient self-management of upper respiratory tract infections. [PDF]

, 2001
OBJECTIVES: To determine the clinical attitudes and behaviour of family doctors in Hong Kong towards patient self-management of upper respiratory tract infections, and factors which may influence this practice.
Lam, KF, Lam, TP
core  

Recent Developments in United Airways Disease [PDF]

, 2012
The nose and lung are both part of the respiratory tract. Often the diseases affecting the nose and/or the bronchi are treated separately. However, in recent years, numerous studies have highlighted the fact that the respiratory system is a single entity
Alvarez, Annesi-Maesano, Baena-Cagnani, Barbi, Baroody, Blaiss, Blanton, Bousquet, Bousquet, Bousquet, Bousquet, Braman, Braunstahl, Braunstahl, Bresciani, Buist, Carmelo Salpietro, Ciprandi, Ciprandi, Ciprandi, Ciprandi, Ciprandi, Ciprandi, Compalati, Corren, Crimi, Crystal-Peters, Davide Caimmi, Davison, Denburg, Dixon, Durham, Fontanari, Gaspar Elsas, Gian Luigi Marseglia, Giorgio Ciprandi, Jacobsen, Jani, Johnston, Jörres, Kapsali, Kauffmann, Mario La Rosa, Marseglia, Meltzer, Michel, Michele Miraglia del Giudice, Miraglia Del Giudice, Mygind, Mygind, Novembre, Pasquali, Passalacqua, Pedersen, Peroni, Platts-Mills, Rachelefsky, Riccio, Saetta, Sehmi, Shaikh, Simons, Sluder, Staikūnienė, Steinke, Stelmach, ten Brinke, The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee, Togias, Tosca, Undem, Valero, Wilson, Wilson   +73 more
core   +2 more sources

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

MV130 in the Prevention of Recurrent Respiratory Tract Infections: A Retrospective Real-World Study in Children and Adults

Vaccines
Respiratory tract infections (RTIs) are among the most common and important problems in clinical medicine, making antibiotics the gold standard therapeutic option regardless of their frequent viral etiology.
Karla Montalbán-Hernández, Ana Cogollo-García, Patricia Girón de Velasco-Sada, Raquel Caballero, Miguel Casanovas, José Luis Subiza, Laura Conejero   +6 more
doaj   +1 more source

Kejadian Ispa Dengan Curah Hujan Dan Kualitas Udara (Pm 10) Di Kabupaten Kapuas, Provinsi Kalimantan Tengah [PDF]

, 2011
Forests burning is one of the major sources of air pollution in the countryside that extends into urban areas. Respiratory tract disease is the biggest number of disease in developing countries.
Mardiana, M. (Mardiana), Sukana, B. (Bambang)   +1 more
core