Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges
Animal Models and Experimental Medicine, EarlyView.Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
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Cytomegalovirus infection in acute respiratory tract disease accompaning hepatitis in infancy.
, 1988 Yusaku Tazawa, Yoshio Numazaki
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Effects of 3-methylindole production and immunity against bovine respiratory syncytial virus on development of respiratory tract disease and rate of gain of feedlot cattle [PDF]
, 2000 Howard R. Bingham +6 more
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Animal Models and Experimental Medicine, EarlyView.Grafts used to construct lung cancer animal models come from various sources, primarily cell lines, patient‐derived tumor tissues, and circulating tumor cells. Based on the sources of grafts and research objectives, lung cancer animal models can be categorized into several types: chemical‐induced models, orthotopic transplantation models, heterotopic ...
Zixuan Yang +7 more
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Diseases of the upper respiratory tract
Upper respiratory tract infections can be defined as self-limited irritation and swelling of the upper airways with associated cough and no signs of pneumonia, in a patient with no other condition that would account for their symptoms, or with no history of chronic obstructive pulmonary disease, emphysema, or chronic bronchitis. Upper respiratory tract
openaire +2 more sources
Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models
Animal Models and Experimental Medicine, EarlyView.We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv +12 more
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Efficacy, Safety, and Tolerability of Nasal Wash in Patients with Upper Respiratory Tract Diseases. [PDF]
Int Arch OtorhinolaryngolLa Mantia I +3 more
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Infectious diseases.1.Disease state and treatment of respiratory tract infection.
, 1993 openalex +2 more sources
Establishment and evaluation of a novel rat model of the fourth ventricle hemorrhage
Animal Models and Experimental Medicine, EarlyView.In this study, a novel rat model of fourth ventricle hemorrhage was established via autologous blood injection through the foramen of Magendie. Anesthetized rats were positioned in a stereotaxic apparatus with their heads tilted downward at an angle of approximately 20° relative to the vertical axis.
Chuhua Fu +8 more
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