Lower respiratory tract co-infection of <i>Streptococcus pneumoniae</i> and respiratory syncytial virus shapes microbial landscape and clinical outcomes in children. [PDF]
Yu X+10 more
europepmc +1 more source
Temporal trends in vaccination and antibiotic use among young children in the United States, 2000-2019. [PDF]
Eiden AL+8 more
europepmc +1 more source
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza+4 more
wiley +1 more source
The impact of environmental factors on respiratory tract microbiome and respiratory system diseases. [PDF]
Ge Y, Tang G, Fu Y, Deng P, Yao R.
europepmc +1 more source
Abstract Objective A benzodiazepine (diazepam or midazolam) is one of the current standards of care therapies to effectively terminate organophosphorus nerve agent‐induced status epilepticus when administered shortly after onset. Preclinical studies showed that benzodiazepines were less effective in stopping status epilepticus when treatment was ...
Hailey G. Steier+8 more
wiley +1 more source
Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials
Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu+4 more
wiley +1 more source
Application of quantitative real-time PCR for identifying respiratory tract pathogens in outpatients with RTIs. [PDF]
Qi L+8 more
europepmc +1 more source
Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis Coinfection
Understanding the immunological basis for severe outcomes in COVID‐19/Tuberculosis coinfection is critical. Our single‐cell analysis identifies key drivers: profound lymphocyte loss through combined apoptosis and altered trafficking, excessive S100 protein‐mediated inflammation contributing to cytokine storms, and systemic immune dysfunction ...
Yi Wang+20 more
wiley +1 more source
Predictive factors for failure of high flow nasal cannula among children with lower respiratory tract infection: A single center retrospective observational study. [PDF]
Sitthikarnkha P+6 more
europepmc +1 more source