Results 311 to 320 of about 910,981 (387)

Pharmacokinetics and Safety of Fenofibrate in Participants with Mild Hepatic Impairment or with Advanced Fibrosis due to Metabolic‐Associated Fatty Liver Disease

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Fenofibrate is contraindicated in patients with advanced hepatic fibrosis due to limited clinical data. We evaluated the pharmacokinetics and safety of fenofibrate in participants with mild hepatic impairment (phase 1 study) or advanced fibrosis due to metabolic‐associated fatty liver disease (MAFLD; phase 2a study).
Islam R. Younis   +5 more
wiley   +1 more source

Factors Associated with Mortality in Nosocomial Lower Respiratory Tract Infections: An ENIRRI Analysis. [PDF]

open access: yesAntibiotics (Basel)
Reyes LF   +39 more
europepmc   +1 more source

Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez   +8 more
wiley   +1 more source

Phage Therapy for Respiratory Tract Infections. [PDF]

open access: yesOpen Respir Arch
Domingo-Calap P   +2 more
europepmc   +1 more source

Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract To assess the antitussive effects of dextrorphan (DOR) relative to its parent compound, dextromethorphan (DEX) a double‐blind, randomized, placebo‐controlled crossover study was conducted in 23 healthy volunteers using citric acid cough challenge test after administering placebo, DEX, or DOR.
Saeed Rezaee   +3 more
wiley   +1 more source

Effect of Urgent ERCP on Clinical Outcomes in Acute Cholangitis With Concurrent Acute Gallstone Pancreatitis: A Propensity Score Matching Analysis

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose Current guidelines do not provide specific recommendations regarding the timing of endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute cholangitis (AC) concurrent with acute gallstone pancreatitis (AGP). This study evaluated the impact of ERCP timing on clinical outcomes.
Mustafa Comoglu   +6 more
wiley   +1 more source

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