Results 131 to 140 of about 27,781,976 (337)

Research on rescue priority based on high spatiotemporal resolution mobile positioning data

Natural Hazards Research
Estimate the key rescue areas of earthquake accurately, which is of great significance for deploying rescue forces and implementing rescue activities in post-earthquake scientifically.This paper based on the idea of first zoning, then classification, and
Na Gao, Jingjing Liu, Lijuan Yuan
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

Science, 2018
V. Gopalakrishnan, C. Spencer, L. Nezi, A. Reuben, M. Andrews, T. Karpinets, P. Prieto, D. Vicente, K. Hoffman, S. Wei, Alexandria P. Cogdill, L. Zhao, C. Hudgens, D. Hutchinson, T. Manzo, M. Petaccia de Macedo, T. Cotechini, T. Kumar, W. Chen, S. Reddy, R. S. Szczepaniak Sloane, J. Galloway-Peña, H. Jiang, P. Chen, E. Shpall, K. Rezvani, A. Alousi, R. Chemaly, S. Shelburne, L. Vence, P. Okhuysen, V. B. Jensen, A. Swennes, F. McAllister, E. Marcelo Riquelme Sanchez, Y. Zhang, E. Le Chatelier, L. Zitvogel, N. Pons, J. Austin-Breneman, L. Haydu, E. Burton, J. Gardner, E. Sirmans, J. Hu, A. Lazar, T. Tsujikawa, A. Diab, H. Tawbi, I. Glitza, W. Hwu, S. Patel, S. Woodman, R. Amaria, M. Davies, J. Gershenwald, P. Hwu, J. Lee, J. Zhang, L. Coussens, Z. Cooper, P. Futreal, C. Daniel, N. Ajami, J. Petrosino, M. Tetzlaff, P. Sharma, J. Allison, R. Jenq, J. Wargo   +69 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Self-protective behavioural responses to fomite-transmitted disease threats

Mathematics in Medical and Life Sciences
This article is part of a Special Issue on “Behavioural Epidemiology“. Mathematical modelling is an important public health tool for aiding the understanding of the spread of respiratory infectious diseases, such as influenza or COVID-19, and for ...
Caroline E. Walters, Maria Bekker-Nielsen Dunbar, Dale Weston, Ian M. Hall   +3 more
doaj   +1 more source

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Science, 2017
Dung T Le, Dung T Le, Jennifer N Durham, Jennifer N Durham, Kellie N. Smith, Hao Wang, Bjarne R. Bartlett, Bjarne R. Bartlett, Laveet K. Aulakh, Laveet K. Aulakh, Steve Lu, Steve Lu, H. Kemberling, C. Wilt, Brandon S. Luber, F. Wong, F. Wong, N. Azad, A. Rucki, D. Laheru, R. Donehower, A. Zaheer, G. Fisher, T. Crocenzi, James J. Lee, T. Greten, A. Duffy, K. Ciombor, A. Eyring, B. Lam, A. Joe, S. Kang, M. Holdhoff, Ludmila V. Danilova, L. Cope, C. Meyer, Shibin Zhou, Shibin Zhou, R. Goldberg, D. Armstrong, K. Bever, A. Fader, J. Taube, F. Housseau, D. Spetzler, N. Xiao, D. Pardoll, N. Papadopoulos, N. Papadopoulos, K. Kinzler, K. Kinzler, J. Eshleman, B. Vogelstein, B. Vogelstein, Robert A. Anders, Robert A. Anders, L. Diaz, L. Diaz   +57 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Age-stratified circulating immune signatures reveal non-invasive biomarkers for colorectal cancer detection

Immunity & Ageing
Ageing is a well-recognised factor influencing immune competence; however, elderly individuals remain underrepresented in clinical trials, resulting in gaps in our understanding of their immune responses to disease.
Julia del Prado-Montero, Jenny Guevara-Martínez, Ramón Cantero-Cid, Pablo Mata-Martínez, Francisco J. Cueto, Roberto Lozano-Rodríguez, Verónica Terrón-Arcos, Rebeca Abad-Moret, Esteban Díaz-Serrano, Rebeca Pérez de Diego, María Fernández-Velasco, Carlos del Fresno, Laura Hurtado-Navarro, Eduardo López-Collazo   +13 more
doaj   +1 more source

Response [PDF]

Chest, 2021
Alexander C, Chen, Gerard A, Silvestri
openaire   +2 more sources