Results 171 to 180 of about 27,781,976 (337)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hepatitis B Virus, Pneumococcal, Diphtheria, and Tetanus Vaccination Responses in Compensated Cirrhosis. [PDF]

Liver Int
Haghnejad V, Lucas M, Chevrier L, Jeulin H, Quilici I, Daude S, Bensenane-Oussalah M, Jacquinot N, Schvoerer E, Batteux F, Bronowicki JP.   +10 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Neurons with graded response have collective computational properties like those of two-state neurons.

Proceedings of the National Academy of Sciences of the United States of America, 1984
J. Hopfield
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

In Response.

Pain physician, 2022
Castien, René, Duineveld, Marc, Maaskant, Joland, De Hertogh, Willem, Scholten-Peeters, Wendy   +4 more
openaire   +4 more sources

Response [PDF]

JNCI: Journal of the National Cancer Institute, 2017
Laurent, Briollais, Robert G, Bristow, Paul C, Boutros, Alexandre R, Zlotta   +3 more
openaire   +2 more sources

Response [PDF]

Chest, 2020
Robert J. Lentz, Fabien Maldonado, Samira Shojaee, Horiana B. Grosu, Otis B. Rickman, Lance Roller, Jasleen K. Pannu, Zachary S. DePew, Labib G. Debiane, Joseph C. Cicenia, Jason Akulian, Charla Walston, Trinidad M. Sanchez, Kevin R. Davidson, Nikhil Jagan, Sahar Ahmad, Christopher Gilbert, John T. Huggins, Heidi Chen, Richard W. Light, Lonny Yarmus, David Feller-Kopman, Hans Lee, Najib M. Rahman   +23 more
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Baseline Alkaline Phosphatase Impacts Response Rates in Primary Biliary Cholangitis: Exploring Response to Elafibranor in ELATIVE. [PDF]

Liver Int
Levy C, Bowlus CL, Lawitz E, Antunes N, Miller B, Shu J, Zein CO, Kowdley KV.   +7 more
europepmc   +1 more source