Results 141 to 150 of about 2,174,140 (265)

Circulating tumor DNA and Response Evaluation Criteria In Solid Tumors: ctDNA-RECIST proof-of-concept in HER2-positive metastatic breast cancer. [PDF]

J Exp Clin Cancer Res
Fabi A, Giordani E, Ricciardi E, Arpino G, Allegretti M, Ferretti G, Omarini C, Zambelli A, Mandoj C, Botticelli A, Bria E, Gori S, Carbognin L, Paris I, Scambia G, Cognetti F, Giannarelli D, Giacomini P.   +17 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

MRI to guide clinical management of rectal cancer: updated consensus recommendations from the European Society of Gastrointestinal and Abdominal Radiology (ESGAR): PART II-Restaging and response evaluation. [PDF]

Eur Radiol
ESGAR Rectal Imaging Guideline Group.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases. [PDF]

EBioMedicine
Crnovrsanin N, Zeeuw JM, Ali M, Kemna R, Alipanahi B, Lumbard K, Skidmore ZL, Rinaldi L, van 't Erve I, Wesdorp NJ, Huiskens J, van Steijn D, van Waesberghe JH, van den Bergh J, Nota I, Moos S, Bond MJG, Meiqari L, Huitink I, Giovannetti E, Stoker J, Verpalen I, van den Broek D, Meijer GA, Swijnenburg RJ, Punt CJA, Scharpf RB, Leal A, Dracopoli NC, Velculescu VE, Kok NFM, Kazemier G, Fijneman RJA.   +32 more
europepmc   +1 more source

The essence and assumptions of evaluation of crisis response operations

Security and Defence Quarterly, 2014
Irmina Denysiuk, Marta Osypowicz
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Feasibility of an artificial intelligence system for tumor response evaluation. [PDF]

BMC Med Imaging
Xiuli N, Hua C, Peng G, Hairong Y, Meili S, Peng Y.   +5 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Multiparametric magnetic resonance imaging for radiotherapy response evaluation in high-risk soft tissue sarcoma: A pilot study. [PDF]

Phys Imaging Radiat Oncol
van Meekeren M, van Houdt PJ, Fiocco M, Winfield JM, Messiou C, Heeres BC, Gelderblom H, Steeghs N, Haas R, van Langevelde K.   +9 more
europepmc   +1 more source