Results 191 to 200 of about 2,704,258 (334)

Deacetylase activities of rHos2 and dose response curves of rHos2 inhibition by standard HDAC inhibitors

, 2013
G. Karthikeyan, Maneesh Paul‐Satyaseela, Nachiappan Dhatchana Moorthy, Radha Gopalaswamy, Shridhar Narayanan   +4 more
openalex   +1 more source

A1169 EFFECTS OF IBUPROFEN ON THE END0T0XIN-INDUCED INHIBITION OF THE PULMONARY PRESSOR RESPONSE TO HYPOXIA IN DOGS [PDF]

, 1990
Yuichi Ishibe, T. Umeda, T. Izumi, Mariko Nakamura, Keita Suekane   +4 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Modulation of response inhibition with event-related atVNS showed EEG but no behavioral effects. [PDF]

Sci Rep
Becker LF, Sallandt GM, Rosolowsky E, Hetzel S, Frings C, Bäumer T, Mückschel M, Beste C, Münchau A.   +8 more
europepmc   +1 more source

Thymidylate synthase inhibition induces p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells

, 2010
Dimitrios J. Stravopodis, Panagiotis K. Karkoulis, Eumorphia G. Konstantakou, Sophia Melachroinou, Angeliki Thanasopoulou, Gerasimos Aravantinos, Lukas H. Margaritis, Ema Anastasiadou, Gerassimos E. Voutsinas   +8 more
openalex   +2 more sources

Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer [PDF]

, 2016
Ke-Jing Tang, Jerfiz D. Constanzo, Niranjan Venkateswaran, Margherita Melegari, Mariya Ilcheva, Julio C. Morales, Ferdinandos Skoulidis, John V. Heymach, David A. Boothman, Pier Paolo Scaglioni   +9 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

The limits of action control for deceptive actions in sports: Response inhibition for the basketball pump fake. [PDF]

PLoS One
Wickemeyer C, Güldenpenning I, Weigelt M.   +2 more
europepmc   +1 more source

Author response: Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation

Yifan Wu, Kunhua Qin, Yi Xu, Shreya Rajhans, Truong Vo, Kevin Lopez, Jun Liu, Michael H Nipper, Janice Deng, Xue Yin, Logan R Ramjit, Zhenqing Ye, Yu Luan, H. Efsun Arda, Pei Wang   +14 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source