Results 251 to 260 of about 13,505,920 (341)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Disentangling the neural underpinnings of response inhibition in disruptive behavior and co-occurring ADHD. [PDF]

Eur Child Adolesc Psychiatry
Saraçaydın G, van Rooij D, Kleine-Deters R, Messchendorp M, Naaijen J, Penzol MJ, Rosa M, Aggensteiner PM, Baumeister S, Holz N, Banaschewski T, Saam M, Schulze UME, Sethi A, Craig M, Castro-Fornieles J, Arango C, Walitza S, Werhahn J, Brandeis D, Franke B, Ruisch IH, Buitelaar JK, Dietrich A, Hoekstra PJ.   +24 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Virtual Reality Gamification of Visual Search, Response Inhibition, and Visual Short-Term Memory Tasks for Cognitive Assessment: Experimental Study. [PDF]

JMIR Form Res
Hadjiaros M, Shimi A, Neokleous K, Pattichis C, Avraamides M.   +4 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Meta-analysis of variance in tDCS effects on response inhibition. [PDF]

Sci Rep
Lasogga L, Gramegna C, Müller D, Habel U, Mehler DMA, Gur RC, Weidler C.   +6 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Impaired response inhibition to negative emotional stimuli in depressed adolescents with non-suicidal self-injury: a neurophysiological perspective. [PDF]

Front Psychiatry
Zhao L, Hong S, Peng X, He X, Hu J, Ma L, Liu X, Tao W, Chen R, Jiang Z, Zhang C, Liao J, Xiang J, Zeng Q, Dai L, Zhang Q, Wang W, Kuang L.   +17 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The effects of isolated game elements on adherence rates in food response inhibition training. [PDF]

R Soc Open Sci
MacLellan A, Pennington CR, Lawrence N, Westwood SJ, Jones A, Slegrova A, Sung B, Parker L, Relph L, Miranda JO, Shakeel M, Mouka E, Lovejoy C, Chung C, Lash S, Suhail Y, Nag M, Button KS.   +17 more
europepmc   +1 more source