Results 111 to 120 of about 711,454 (295)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Changes in the Dose–Response Relationship of One Toxicant Under Simultaneous Exposure to Another Toxicant

Dose-Response, 2016
We considered, in general form for a 2 2 full factorial experiment, linear approximations of the organism’s dose–response relationship for some factors operating alone and modification of this relationship by another factor operating in the background. A
B. A. Katsnelson, V. G. Panov, A. N. Varaksin, I. A. Minigalieva, L. I. Privalova, M. P. Sutunkova   +5 more
doaj   +1 more source

Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α [PDF]

, 2013
Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B ...
Unlu, Sebnem, Gillian M. Tannahill (440532), O’Neill Luke A., Kent Z. Q. Wang (440530), Kent Z. Q. Wang, Galson, Deborah L., Galson Deborah L., Luke A. O’Neill (440534), Tannahill Gillian M., Auron Philip E., O'Neill, LA, Adamik, Juraj, Su An-Jey A., Gillian M. Tannahill, Sebnem Unlu, Philip E. Auron, Unlu Sebnem, Gillian M Tannahill, Adamik, J, An-Jey A. Su, Yan, Chunhong, Auron, PE, Deborah L. Galson, Luke A. O’Neill, Luke A O'Neill, O’Neill, Luke A., Su, AJA, Tannahill, GM, An-Jey A. Su (440531), O\u27Neill, Luke A., Deborah L Galson, Wang, KZQ, An-Jey A Su, Kent Z Q Wang, Unlu, S, Sebnem Unlu (156119), Wang, Kent Z. Q., Juraj Adamik (440529), Galson, DL, Adamik Juraj, Philip E. Auron (440535), Philip E Auron, Wang Kent Z. Q., Su, An Jey A., Tannahill, Gillian M., Su, An-Jey A., Wang, Kent Z.Q., Deborah L. Galson (440533), Auron, Philip E., Juraj Adamik   +49 more
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Nature Communications, 2018
Following double-strand break a cascade of events leads to the recruitment of repair factors to damaged sites. Here the authors identify ZNF506 as a key factor that mediates post-translational modification changes in H2AX affecting the DNA damage ...
Somaira Nowsheen, Khaled Aziz, Kuntian Luo, Min Deng, Bo Qin, Jian Yuan, Karthik B. Jeganathan, Jia Yu, Henan Zhang, Wei Ding, Jan M. van Deursen, Zhenkun Lou   +11 more
doaj   +1 more source

Seismic Response Modification Factorof Reinforced Concrete Frames Basedon Pushover Analysis

, 2019
Response modification factor is an essential factor in seismic analysis to provide economic design of reinforced concrete structures. Base shear force is divided by the response modification factor to consider the ability of the structure to dissipate ...
Mohamed, Amira Elyamany, El-Degwy, Wael M., Attia, Walid A   +2 more
core  

Response modification factors for steel buckling restrained braced frames designed as per NBCC 2010

, 2016
This paper evaluates the overstrength, ductility and response modification factors for low to mid-rise Buckling Restrained Braced Frames (BRBFs) designed as per the National Building Code of Canada (NBCC) 2010.
Alam, M. Shahria, Moni, Moniruzzaman, Moradi, Saber   +2 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Modification of response reduction factors of overhead water tanks based on ductility factor

Discover Applied Sciences
AbstractIn the earthquake-resistant design of overhead tanks, this research dealt with the determination of the response reduction factor applicable to overhead water tanks performing beyond the elastic limit. Eight existing water tanks were selected for the investigation and 127 ground accelerations due to 10 Indian earthquakes were selected.
Antony Vimal Paul Pandian, Krishna Prakash Arunachalam, Siva Avudaiappan, S. Sahaya Jasmin, Lenin Miguel Bendezú Romero, Paul O. Awoyera   +5 more
openaire   +2 more sources

Construct validity, dimensionality and factorial invariance of the Rosenberg Self Esteem Scale: A bifactor modelling approach among children of prisoners

, 2014
The Rosenberg Self Esteem Scale (RSES; Rosenberg, 1989) has traditionally been conceptualised as a unidimensional measure of self-esteem but empirical evidence is equivocal, with some studies supporting a one-factor solution and others favouring ...
Daniel Boduszek, Gallagher, Bernard, Adele Jones, Sharratt, Kathryn, Bernard Gallagher, Jones, Adele, Kathryn Sharratt, Boduszek, Daniel   +7 more
core   +1 more source