Results 41 to 50 of about 1,756,114 (279)

EZH2, HIF-1, and their inhibitors: An overview on pediatric cancers [PDF]

, 2018
During the past decades, several discoveries have established the role of epigenetic modifications and cellularmicroenvironment in tumor growth and progression. One of the main representatives concerning epigenetic modification is the polycomb group (PcG)
Antonello Mai, Diana Bellavia, Elisabetta Ferretti, Elisabetta Ferretti, Giuseppe Battaglia, Marco Papale, Marco Tafani   +6 more
core   +2 more sources

Ductility Evaluation of inverted V-bracing and concentrically bracing systems [PDF]

Journal of Structural and Construction Engineering, 2019
The current design philosophy for buildings located in zones with high seismic risks is that the buildings must have sufficient strength and stiffness to remain elastic and serviceable under moderate but frequently occurring earthquakes and to have ...
Abazar Asghari
doaj   +1 more source

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]

, 2014
Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention.
Bown, James L., Goltsov, Alexey, Goltsov, Gregory, Harrison, David J., Langdon, Simon P.   +4 more
core   +5 more sources

Non-mammalian model organisms in epigenetic research : an overview [PDF]

, 2020
Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik, Bossier, Peter, Norouzitallab, Parisa, Vanrompay, Daisy   +3 more
core   +2 more sources

Response Modification Factor of High-Strength Steel Frames with D-Eccentric Brace Using the IDA Method

Buildings
The design innovation of high-strength steel frames paired with D-eccentric bracing exhibits remarkable resistance to plastic deformation during seismic events.
Yan Ma, Jun Yang, Xiaotong Ma
doaj   +1 more source

Evaluating Equivalent Damping and Response Modification Factors of Frames Equipped by Pall Friction Dampers [PDF]

Journal of Rehabilitation in Civil Engineering, 2013
A study on the evaluating equivalent damping and response modification factors of frames equipped by Pall Friction Dampers is presented. To do so, buildings with various stories were considered. Nonlinear and linear dynamic time history analysis has been
M. Mahmoudi, A. Mirzaei, S. Vosough
doaj   +1 more source

Analysis of N6-Methyladenosine Modification Patterns and Tumor Immune Microenvironment in Pancreatic Adenocarcinoma

Frontiers in Genetics, 2022
Background: Pancreatic adenocarcinoma (PAAD) is a rare cancer with a poor prognosis. N6-methyladenosine (m6A) is the most common mRNA modification.
Yong Liu, Guangbing Li, Yang Yang, Ziwen Lu, Tao Wang, Xiaoyu Wang, Jun Liu, Jun Liu   +7 more
doaj   +1 more source

Temperature enhanced effects of ozone on cardiovascular mortality in 95 large US communities, 1987-2000 - assessment using the NMMAPS data [PDF]

, 2009
A few studies examined interactive effects between air pollution and temperature on health outcomes. This study is to examine if temperature modified effects of ozone and cardiovascular mortality in 95 large US cities.
Cizao Ren, Gail M. Williams, Kerrie Mengersen, Lidia Morawska, Ren C, Sharma H S, Shilu Tong   +6 more
core   +2 more sources

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source