Results 141 to 150 of about 15,971,534 (326)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Regime-switching Vector Error Correction Model (VECM) analysis of UK meat consumption [PDF]
The asymptotic distributions of cointegration tests are approximated using the Gamma distribution. The tests considered are for the I(1), the conditional I(1), as well as the I(2) model.
Kostov, Phillip, Lingard, John
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
MODELING THE POTENTIAL HAZARD OF WATER EROSION OF SOILS
Мелиорация и гидротехникаPurpose: to create digital models of water erosion factors in the form of parametric response surfaces and systems of point equations and to determine functional links between them and the geometric parameters of the micro- and nanorelief of a soil ...
Alexander I. Karaiev +2 more
doaj +1 more source
Unsteady pressure and structural response measurements of an elastic supercritical wing [PDF]
Results are presented which define unsteady flow conditions associated with high dynamic response experienced on a high aspect ratio elastic supercritical wing at transonic test conditions while being tested in the NASA Langley Transonic Dynamics Tunnel.
Eckstrom, Clinton V. +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Mechanical Behaviour of Stamped Aluminium Alloy Components by Means of Response Surfaces. [PDF]
Materials (Basel), 2019 Cuesta II +2 more
europepmc +1 more source
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2015 C. Gevaert +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source