Results 191 to 200 of about 7,672,625 (230)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Connecting process models to response times through Bayesian hierarchical regression analysis. [PDF]

Behav Res Methods
Behrens T, Kühn A, Jäkel F.
europepmc   +1 more source

Corrigendum: ExGUtils: A Python Package for Statistical Analysis With the ex-Gaussian Probability Density

Frontiers in Psychology, 2018
Carmen Moret-Tatay, Daniel Gamermann, Esperanza Navarro-Pardo, Pedro Fernández de Córdoba Castellá   +3 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Assessment of Emergency Medical Service (EMS) response times and operational factors in out-of-hospital cardiac arrests (OHCA): a retrospective analysis. [PDF]

Postepy Kardiol Interwencyjnej
Goniewicz M, Bednarz K, Al-Wathinani AM, Goniewicz K.   +3 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Neural representations of letters in human medial temporal lobe predict working memory response times

Costa F, Ledergerber D, Imbach L, Sarnthein J.   +3 more
europepmc   +1 more source

Modelling emergency response times for Out-of-Hospital Cardiac Arrest (OHCA) patients in rural areas of the North of England using routinely collected data. [PDF]

BMC Emerg Med
Harries M, Ushakova A.
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Are brake response times altered post CT-guided cervical spine nerve root injections? [PDF]

Br J Radiol
Hanley M, Eustace SK, Ryan DT, McLoughlin S, Hynes JP, Kavanagh EC, Eustace SJ.   +6 more
europepmc   +1 more source