Results 61 to 70 of about 1,419,624 (297)
Politeja, 2018 The article presents the evolution of the approach to humanitarian intervention that in the 21st century had been framed in the concept of Responsibility to Protect.
Jakub Kościółek
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Assessing the Responsibility to Protect: moving from theory to practice [PDF]
, 2016 In his recent article on the Responsibility to Protect – a political commitment to prevent atrocities – Matt Sleat argued it would be wrong to assess its success solely on how far it conforms to moral principles, while ignoring the difficult political ...
Sleat, Matt
core
No Child Left Behind: The Adam Walsh Act and Pennsylvania Juvenile Sex Offenders [PDF]
, 2008 At a White House ceremony on July 27, 2006, President Bush signed into law the Adam Walsh Child Protection and Safety Act of 2006. At the ceremony, the President hailed the Walsh Act as being comprehensive and an important part of the “solemn ...
Wilson, Neal F.
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The international community’s Responsibility to Protect [PDF]
Forced Migration Review, 2008 In the face of continuing grave violations of human rightsby the Burmese government against its own civilians, it isimperative that the international community start torespond to Burma in terms of the Responsibility to Protect(R2P) principle.
Kavita Shukla
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
The marginal morality (die Grenzen der Moral) as an ethical challenge and as the knowledge on how to gain competitive advantage [PDF]
, 2017 The aim of this article is to scrutinize the relationship between the moral attitude of an entrepreneur and his or her possibility to gain competitive advantage. This declaration leads to the following question: does the everyday practice confirm or deny
Rotengruber, Przemysław
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source