Results 91 to 100 of about 1,170,184 (286)
Ethical (responsible) leadership
Theoria, Beograd, 2021 The paper, from the perspective of ethical theories, presents and analyzes the aspects of morality that fall under responsible leadership in the field of business ethics. It is an assumption that the idea of responsible leadership is derived from the aspect of morality that is governed by interest, which can be disguised for the sake of ...
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Integrity,Respect for Others,and Ethics-Three Essential Leadership Qualities [PDF]
, 2011 requisites for leadership. Unfortunately many so called leaders do not understand or practise these values. Some leaders who are held with high regard and esteem at the workplace are prepared to sacrifice a life time's achievement and reputation within
Ojo, Mariane.B.
core +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Green shared vision: A bridge between responsible leadership and green behavior under individual green values. [PDF]
Heliyon, 2023 Younas N +6 more
europepmc +1 more source
Context-Responsive Leadership: Examining Superintendent Leadership in Context.
Education Policy Analysis Archives, 2011 It is widely acknowledged that context matters, that it affects leadership practices. A large body of descriptive studies documents common elements in the work of school superintendents. What is less well known is how superintendents’ leadership may be expressed very differently given the varying contexts in which they work.
Bredeson, Paul V. +2 more
openaire +4 more sources
Management education and the ethical mindset: Responsibility to whom and for what? [PDF]
, 2013 Paper presented at the European Business Ethics Network (UK) Conference, Ethics in Crisis: a call for alternatives, April 7-9, 2010 at Queen Mary, University of London. Final version published by Springer in Journal of Business Ethics.
Bird, Fred +2 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source