Results 111 to 120 of about 2,951,975 (308)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Co-Determination in Germany: 1949-1979 and There Beyond: Bonding or Compulsion? [PDF]
Co-determination refers to a set of rules and institutions which form an interlocking system and as such provide the unique structure of German corporate governance. This essay deals with the reasons responsible for bringing the structure about.
Backhaus,Jürgen G.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
EDUCATIONAL BUSINESS IN INDONESIA: ITS SCIENTIFIC QUALITY AND PROFESSIONAL BUSINESS CHALLENGE [PDF]
This study discovers concept and principles to become new theories regarding educational business, study business theories with regard to educational business format, business planning, strategic management, marketing management, financial management and
Enjang Sudarman
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
THE CAPACITY OF INTERNATIONAL ORGANIZATIONS TO BEAR INTERNATIONAL RESPONSIBILITY [PDF]
Challenges of the Knowledge Society, 2015 The status of international personality is not exclusively reserved for states. In modern days, the international organizations have legal international personality and also have the capacity to be internationally responsible for their conduct.
Ovidiu-Emilian IVANESCU
doaj
Corporate Social Responsibility in Romanian Companies – between Perceptions and Reality [PDF]
Starting with the premise that corporate social responsibility is a major factor for lasting development in a global economic society, this article sets forth an analysis of the realities and tendencies within the Romanian CSR. The present article offers
Ciprian Obrad +3 more
core
Spatiotemporal organization of energy release events in the quiet solar corona
, 2014 Using data from STEREO and SOHO spacecraft, we show that temporal organization of energy release events in the quiet solar corona is close to random, in contrast to the clustered behavior of flaring times in solar active regions.
Davila, Joseph M., Uritsky, Vadim M.
core +1 more source