Results 61 to 70 of about 1,193,547 (261)
This article traces the evolution of representative claim-making by the Chinese Communist Party (CCP) since the proclamation of the People’s Republic of China in 1949 up to the present day.
Emilie Frenkiel, Anna Shpakovskaya
doaj +1 more source
Moral Hedging and Responding to Reasons [PDF]
In this paper, I argue that the fetishism objection to moral hedging fails. The objection rests on a reasons-responsiveness account of moral worth, according to which an action has moral worth only if the agent is responsive to moral reasons. However, by
Hicks, Amelia
core
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The MS Symptom and Impact Diary (MSSID): psychometric evaluation of a new instrument to measure the day to day impact of multiple sclerosis [PDF]
OBJECTIVES: This study aimed to develop further a diary originally devised to measure the impact of multiple sclerosis (MS) as part of a cost utility study of beta interferon, and to evaluate its reliability, validity, and responsiveness in an ...
Ford, H +3 more
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Assessing health systems' responsiveness in tackling COVID-19 pandemic
Health systems' responsiveness is the key to addressing infectious disease threats such as pandemics. The article outlines an assessment of health systems based on World Health Organization's building blocks for select countries.
Sutapa Bandyopadhyay Neogi, G S Preetha
doaj +1 more source
A generalised approach to torsionality maximisation in longitudinal-torsional ultrasonic devices [PDF]
A longitudinal-torsional vibration mode has many applications in ultrasonic systems. Obtaining this behaviour could be achieved either by coupling the longitudinal and torsional modes or by degenerating the longitudinal mode, but the results may be ...
Al-Budairi, Hassan +2 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source

