Results 181 to 190 of about 7,840,073 (343)

The Long-Term Prognostic Role of Nighttime Resting Heart Rate in Obstructive Sleep Apnea in Patients with Acute Coronary Syndrome

, 2023
Qingjie Xin, Hui Ai, Wei Gong, Wen Zheng, Xiao Wang, Yan Yan, Bin Que, Siyi Li, Zekun Zhang, Xiuhuan Chen, Yun Zhou, Jingyao Fan, Shaoping Nie   +12 more
openalex   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Resting-state test–retest reliability of a priori defined canonical networks over different preprocessing steps

, 2016
Deepthi P. Varikuti, Felix Hoffstaedter, Sarah Genon, Holger Schwender, Andrew Reid, Simon B. Eickhoff   +5 more
openalex   +2 more sources

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

JAMA Neurology, 2018
E. Musiek, Meghana Bhimasani, Margaret A. Zangrilli, J. Morris, D. Holtzman, Yo-El S Ju   +5 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The interaction between RE1-silencing transcription factor (REST) and heat shock protein 90 as new therapeutic target against Huntington’s disease

, 2019
Raúl Orozco-Díaz, Angélica Sánchez-Álvarez, J. Manuel Hernández‐Hernández, José Tapia-Ramı́rez   +3 more
openalex   +2 more sources

Resting State Functional Connectivity is Decreased Globally Across the C9orf72 Mutation Spectrum [PDF]

, 2020
Rachel F. Smallwood Shoukry, Michael G. Clark, Mary Kay Floeter   +2 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Cerebral Microcirculatory Blood Flow Dynamics During Rest and a Continuous Motor Task [PDF]

, 2019
Martin Müller, Mareike Österreich
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source