Results 211 to 220 of about 7,840,073 (343)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Pharmacological inhibition of RE1 silencing transcription factor disrupts SOX2 expression and neurogenesis in human induced pluripotent stem cells derived neuronal models. [PDF]

Metab Brain Dis
Nassar A, Hegde S, Chandran D, Pahadasingh S, Nayak A, Satarker S, Gurram PC, Upadhya D, Nampoothiri M.   +8 more
europepmc   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A Novel Ultrasound Assessment Technique of the Ulnar Collateral Ligament to Account for the Valgus Stress Effect of Gravity on the Medial Elbow. [PDF]

Orthop J Sports Med
Colberg RE, Vega TF, Towns J, Yates AF, Westbrooks B, Carlson S, Fleisig GS, Ithurburn MP.   +7 more
europepmc   +1 more source

A modified fluorescent microsphere-based approach for determining resting and hyperemic blood flows in individual murine skeletal muscles

, 2007
Trevor R. Cardinal, James B. Hoying
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Disrupted rest-task shift of multi-band electroencephalography complexity in patients with schizophrenia. [PDF]

Schizophrenia (Heidelb)
Tamura S, Iwasaki T, Ichikawa O, Nishigori K, Iwamura Y, Fujimoto T, Tamada T, Nagata H, Hirano Y.   +8 more
europepmc   +1 more source

Long-duration bed rest as an analog to microgravity.

Journal of applied physiology, 2016
A. Hargens, L. Vico
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The Fifth Hurricane Hazard: A Case Study of Heat Risks Faced by Disaster Relief Workers After Hurricane Beryl's Landfall. [PDF]

Geohealth
Grundstein A, Shepherd JM, Stearns R, Ritchie M.   +3 more
europepmc   +1 more source