Results 71 to 80 of about 2,693 (98)

Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients

Frontiers in Neuroanatomy, 2017
Familial Parkinson's disease (PD) is often caused by mutation of a certain gene, while sporadic PD is associated with variants of genes which can influence the susceptibility to PD. The goal of this study was to investigate the difference between the two
Yan Tang, Yan Tang, Xue Xiao, Hua Xie, Chang-min Wan, Li Meng, Zhen-hua Liu, Wei-hua Liao, Bei-sha Tang, Bei-sha Tang, Bei-sha Tang, Bei-sha Tang, Bei-sha Tang, Ji-feng Guo, Ji-feng Guo   +14 more
doaj   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

DDSurfer: A Weakly‐Supervised Dual‐Stream Deep Learning Framework for Cortical Surface Reconstruction From Diffusion MRI

Advanced Science, EarlyView.
DDSurfer reconstructs cortical surfaces directly from diffusion MRI without requiring T1‐weighted scans. By fusing complementary microstructural features and learning diffeomorphic deformations, it efficiently generates accurate white matter and pial surfaces, improving geometric fidelity and morphometric reliability across datasets for robust surface ...
Chengjin Li, Wei Zhang, Xi Zhu, Yuqian Chen, Nir A. Sochen, Jarrett Rushmore, Carl‐Fredrik Westin, Yogesh Rathi, Lauren J. O'Donnell, Ofer Pasternak, Fan Zhang   +10 more
wiley   +1 more source

Metal Battery Anode: Rich in Electrons, Rich in Problems: A Critical Review from Industrial Perspectives

Advanced Science, EarlyView.
Metal‐anode batteries using Li, Na, Mg, and Ca offer exceptionally high energy density, but dendrites, unstable interphases, cracking, and pore formation hinder durability and safety. This review shows how careful electrolyte and interphase design can stabilize these reactive metals.
Jian Pan, Chan Shu, Oscar Tutusaus, Rana Mohtadi   +3 more
wiley   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Abnormal resting-state brain activities in patients with first-episode obsessive-compulsive disorder

Neuropsychiatric Disease and Treatment, 2017
Qihui Niu,1,* Lei Yang,1,* Xueqin Song,1 Congying Chu,2 Hao Liu,1 Lifang Zhang,1 Yan Li,1 Xiang Zhang,1 Jingliang Cheng,1 Youhui Li1 1Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 2Brainnetome Certer ...
Niu Q, Yang L, Song X, Chu C, Liu H, Zhang L, Li Y, Zhang X, Cheng J, Li Y   +9 more
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The role of ultra-high field MRI and image processing in the presurgical workup in MRI-negative focal epilepsy: A validated 7T MRI case study

Epilepsy & Behavior Reports
This case study demonstrates the value of combined 7 T structural and functional MRI in the presurgical workup of a 24-year-old male with drug-resistant focal epilepsy who was initially considered MRI-negative on clinical 3 T MRI.
Daniel Uher, Gerhard S. Drenthen, Christianne M. Hoeberigs, Rick H.G.J. van Lanen, Albert J. Colon, Roy A.M. Haast, Vivianne H.J.M. van Kranen-Mastenbroek, Guido Widman, Paul A.M. Hofman, Louis G. Wagner, Jan C. Beckervordersandforth, Jacobus F.A. Jansen, Olaf E.M.G. Schijns, Walter H. Backes   +13 more
doaj   +1 more source

Clinical Application of Resting-State Functional MRI for Individualized Localization of Core Language Areas in Patients with Drug-Resistant Epilepsy: An Observational Study

Neuropsychiatric Disease and Treatment
Meng Wang,1,2,* Xuehua Cui,1,2,* Ya Zhang,3 Ruxue Wang,4 Yuxiang Yan,4 Lixia Zhou,5 Zhenzeng Fan,1,2 Wenling Li1,21Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, People’s Republic of ...
Wang M, Cui X, Zhang Y, Wang R, Yan Y, Zhou L, Fan Z, Li W   +7 more
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Time varying analysis of dynamic resting-state functional brain network to unfold memory function

Neuroscience Informatics
Recent advances in brain network analysis are largely based on graph theory methods to assess brain network organization, function, and malfunction. Although, functional magnetic resonance imaging (fMRI) has been frequently used to study brain activity ...
Tahmineh Azizi
doaj   +1 more source

Resting-State Functional MRI Study Demonstrates That the Density of Functional Connectivity Density Mapping Changes in Patients with Acute Eye Pain

Journal of Pain Research, 2020
Zhou Zhou,1– 3 Pei-Wen Zhu,3 Wen-Qing Shi,3 You-Lan Min,3 Qi Lin,3 Qian-Min Ge,3 Biao Li,3 Qing Yuan,3 Yi Shao3 1Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, People’s Republic of China ...
Zhou Z, Zhu PW, Shi WQ, Min YL, Lin Q, Ge QM, Li B, Yuan Q, Shao Y   +8 more
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