Results 41 to 50 of about 7,568,295 (241)

The male to female ratio at birth [PDF]

, 2014
The factors that influence the male to female ratio at birth are legion. Males are usually born in excess and stress decreases the ratio while wellbeing and good health tends to increase it.
Mamo, Julian, Grech, Victor E.
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

A probabilistic model for the high cycle fatigue behaviour of cast aluminium alloys subject to complex loads [PDF]

, 2013
Lien vers la version éditeur: http://www.sciencedirect.com/science/article/pii/S0142112312002472This article is dedicated to the high cycle fatigue behaviour of cast hypo-eutectic Al–Si alloys and in particular the AlSi7Cu05Mg03 alloy.
PESSARD, Etienne, MOREL, Franck, BELLETT, Daniel, KOUTIRI, Imade   +3 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Physiology guided coronary revascularization using a hybrid RFR-FFR strategy for Non ST elevation acute coronary syndrome

Scientific Reports
To develop a hybrid resting full-cycle ratio (RFR)- fractional flow reserve (FFR) decision-making approach for physiology-guided coronary revascularization in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).
Huanting Liu, Youcheng Wang, Sini Fang, Xu Liu, Mao Jiang, Ming Chen, Nan Guo, Yunfei Wang, Jing Yu, Yumeng Lei, Ying Mao, Liqiu Yan   +11 more
doaj   +1 more source

Effectiveness of Fractional Flow Reserve and Resting Full-Cycle Ratio In Arteries with Tandem Stenosis

Journal of Biomechanics
Coronary artery disease, associated with significant mortality and morbidity, is caused by atherosclerotic stenoses (blood vessel cholesterol blockages) obstructing coronary blood flow. Stenoses may be widespread, with several occurring in one coronary artery.
Tam Atkins, Navid Freidoonimehr, John Beltrame, Maziar Arjomandi   +3 more
openaire   +4 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source