Results 61 to 70 of about 9,964,414 (335)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Latent functional connectivity underlying multiple brain states

Network Neuroscience, 2022
Functional connectivity (FC) studies have predominantly focused on resting state, where ongoing dynamics are thought to reflect the brain’s intrinsic network architecture; thought to be broadly relevant because it persists across brain states (i.e ...
Ethan M. McCormick, Katelyn L. Arnemann, Takuya Ito, Stephen José Hanson, Michael W. Cole   +4 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Resting-state “Physiological Networks” [PDF]

, 2019
AbstractSlow changes in systemic brain physiology can elicit large fluctuations in fMRI time series, which may manifest as structured spatial patterns of temporal correlations between distant brain regions. These correlations can appear similar to large-scale networks typically attributed to coupled neuronal activity.
Chen, Jingyuan E., Lewis, Laura D., Chang, Catie, Fultz, Nina E., Ohringer, Ned A., Rosen, Bruce R., Polimeni, Jonathan R.   +6 more
openaire   +1 more source

Functional connectomics from resting-state fMRI [PDF]

Trends in Cognitive Sciences, 2013
Spontaneous fluctuations in activity in different parts of the brain can be used to study functional brain networks. We review the use of resting-state functional MRI (rfMRI) for the purpose of mapping the macroscopic functional connectome. After describing MRI acquisition and image-processing methods commonly used to generate data in a form amenable ...
Smith, S, Vidaurre, D, Beckmann, C, Beckmann, C, Beckmann, C, Glasser, M, Jenkinson, M, Miller, K, Nichols, T, Nichols, T, Robinson, E, Salimi-Khorshidi, G, Woolrich, M, Woolrich, M, Barch, D, Uǧurbil, K, Van Essen, D   +16 more
openaire   +4 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Alterations in resting-state activity relate to performance in a verbal recognition task. [PDF]

PLoS ONE, 2013
In the brain, resting-state activity refers to non-random patterns of intrinsic activity occurring when participants are not actively engaged in a task.
Rocío A López Zunini, Jean-Philippe Thivierge, Shanna Kousaie, Christine Sheppard, Vanessa Taler   +4 more
doaj   +1 more source

The Effect of Aging on Resting State Connectivity of Predefined Networks in the Brain

Frontiers in Aging Neuroscience, 2019
Recent studies have found a deleterious effect of age on a wide variety of measures of functional connectivity, and some hints at a relationship between connectivity at rest and cognitive functioning.
Eleanna Varangis, C. Habeck, Q. Razlighi, Y. Stern   +3 more
semanticscholar   +1 more source

Altered resting state complexity in schizophrenia [PDF]

NeuroImage, 2012
The complexity of the human brain's activity and connectivity varies over temporal scales and is altered in disease states such as schizophrenia. Using a multi-level analysis of spontaneous low-frequency fMRI data stretching from the activity of individual brain regions to the coordinated connectivity pattern of the whole brain, we investigate the role
Danielle S, Bassett, Brent G, Nelson, Bryon A, Mueller, Jazmin, Camchong, Kelvin O, Lim   +4 more
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source