Results 71 to 80 of about 921,081 (288)

Altered resting state complexity in schizophrenia [PDF]

NeuroImage, 2012
The complexity of the human brain's activity and connectivity varies over temporal scales and is altered in disease states such as schizophrenia. Using a multi-level analysis of spontaneous low-frequency fMRI data stretching from the activity of individual brain regions to the coordinated connectivity pattern of the whole brain, we investigate the role
Danielle S, Bassett, Brent G, Nelson, Bryon A, Mueller, Jazmin, Camchong, Kelvin O, Lim   +4 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Functional Interactions between Cortical Regions through Theta-Gamma Coupling during Resting-State and a Visual Working Memory Task

Brain Sciences, 2022
Theta phase-gamma amplitude coupling (TGC) plays an important role in several different cognitive processes. Although spontaneous brain activity at the resting state is crucial in preparing for cognitive performance, the functional role of resting-state ...
Ji Seon Ahn, Jaeseok Heo, Jooyoung Oh, Deokjong Lee, Kyungun Jhung, Jae-Jin Kim, Jin Young Park   +6 more
doaj   +1 more source

Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study. [PDF]

, 2015
Brain network activity associated with altered motor control in individuals with chronic pain is not well understood. Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a debilitating condition in which previous studies have revealed altered ...
Apkarian, A Vania, Asavasopon, Skulpan, Ashe-McNalley, Cody, Clauw, Daniel J, Cosand, Louise, Deutsch, Georg, Farmer, Melissa A, Harris, Richard E, Johnson, Kevin A, Kilpatrick, Lisa A, Kirages, Daniel J, Kutch, Jason J, Labus, Jennifer S, Mackey, Sean C, Mayer, Emeran A, Mullins, Chris, Ness, Timothy J, Rana, Manku, Yani, Moheb S   +18 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Spontaneous Associations under Mild Compression of the Hippocampal Area

Вестник Московского университета. Серия 14: Психология
Background. The network principle of cognitive phenomena implementation in the brain presupposes self-organization of distributed neuronal elements into a network for processing information demanded by the organism at a given moment.
Olga A. Krotkova , Arina N. Kiseleva , Alesia S. Bichkova , Mariya U. Kaverina   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Stress Impact on Resting State Brain Networks. [PDF]

PLoS ONE, 2013
Resting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal
José Miguel Soares, Adriana Sampaio, Luís Miguel Ferreira, Nadine Correia Santos, Paulo Marques, Fernanda Marques, Joana Almeida Palha, João José Cerqueira, Nuno Sousa   +8 more
doaj   +1 more source

Fractal analysis of resting state functional connectivity of the brain [PDF]

, 2012
A variety of resting state neuroimaging data tend to exhibit fractal behavior where its power spectrum follows power-law scaling. Resting state functional connectivity is significantly influenced by fractal behavior which may not directly originate from ...
Achard, Sophie, Brückner, Bernd, Seiffert, Udo, Stadler, Jörg, You, Wonsang   +4 more
core   +5 more sources