Results 111 to 120 of about 1,008,388 (323)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Dynamic recruitment of resting state sub-networks [PDF]
NeuroImage, 2015 Resting state networks (RSNs) are of fundamental importance in human systems neuroscience with evidence suggesting that they are integral to healthy brain function and perturbed in pathology. Despite rapid progress in this area, the temporal dynamics governing the functional connectivities that underlie RSN structure remain poorly understood.
George C. O'Neill +5 more
openaire +2 more sources
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
When the systems fail to communicate. Cerebral resting state networks in schizophrenia spectrum disorders. [PDF]
, 2014 There have been numerous attempts to reveal the neurobiological basis of schizophrenia spectrum disorders. Results however, remain as heterogeneous as the schizophrenia spectrum disorders itself.
Razavi, Nadja
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
The Impact of Normalization and Segmentation on Resting-State Brain Networks [PDF]
Brain Connectivity, 2015 Graph theory has recently received a lot of attention from the neuroscience community as a method to represent and characterize brain networks. Still, there is a lack of a gold standard for the methods that should be employed for the preprocessing of the data and the construction of the networks, as well as a lack of knowledge on how different ...
Ricardo Magalhães +4 more
openaire +3 more sources
Alterations of Directional Connectivity among Resting-State Networks in Alzheimer Disease [PDF]
, 2013 BACKGROUND AND PURPOSE: AD has been documented as a kind of disconnection syndrome by functional neuroimaging studies. The primary focus of this study was to examine, with the use of resting-state fMRI, whether AD would impact connectivity among RSNs ...
Wu, X (reprint author), Beijing Normal Univ, Sch Informat Sci & Technol, Beijing 100875, Peoples R China. +6 more
core
Spectral signatures of reorganised brain networks in disorders of consciousness [PDF]
, 2014 Theoretical advances in the science of consciousness have proposed that it is concomitant with balanced cortical integration and differentiation, enabled by efficient networks of information transfer across multiple scales. Here, we apply graph theory to
Valdas Noreika (645566) +65 more
core +1 more source
Parallel ICA identifies sub-components of resting state networks that covary with behavioral indices
Frontiers in Human Neuroscience, 2012 Parallel Independent Component Analysis (para-ICA) is a multivariate method that can identify complex relationships between different data modalities by simultaneously performing Independent Component Analysis on each data set while finding mutual ...
Timothy eMeier +19 more
doaj +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source