Results 221 to 230 of about 96,125 (306)

Priority questions for the next decade of blue carbon science. [PDF]

Nat Ecol Evol
Macreadie PI, Biddulph GE, Masque P, Kennedy H, Samper-Villarreal J, Patrick Megonigal J, Morrissette HK, Romero-Gonzalez TE, Hatje V, Friedrich J, Sasmito SD, Watanabe K, Mazarrasa I, Krause-Jensen D, Adams JB, Cifuentes-Jara M, Arias-Ortiz A, Rovai AS, Stankovic M, Isensee K, Queirós AM, Chen L, Herrera-Silveira J, Hurd CL, Ismail R, Krauss KW, Lafratta A, Palacios MM, Austin WEN.   +28 more
europepmc   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

Identifying ecological restoration zones based on ecological security patterns in a resource transitioning district. [PDF]

Sci Rep
Ma Y, Wang R, Wang Y, Ci H, Yang H, Teng J, Zhu B, Gu Y, Yuan Y, Zhu Y, Chen J.   +10 more
europepmc   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Trade-offs, synergies and scale effects of ecosystem services in the middle reaches of the Yellow River. [PDF]

Sci Rep
Zhang HX, Xu WJ, Xi MH, Li KM, Fan XW, Ren TY, Liu JW.   +6 more
europepmc   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Freshwater habitats within the Natura 2000 network. [PDF]

Ecol Appl
Baattrup-Pedersen A, Baumane M, Nielsen A, Trolle D, Branco P, Borgwardt F, Hering D, Birk S.   +7 more
europepmc   +1 more source

Northern Peatlands in Transition in the 21st Century - Land Use, Status, Policies and Future Trajectories: Comparisons Between Finland, Ireland and Scotland. [PDF]

Environ Manage
Lampela M, Renou-Wilson F, Andersen R, Wilson D, Artz RRE, Clilverd H, Turunen J, Tolvanen A, Maanavilja L, Laine AM.   +9 more
europepmc   +1 more source

Restoration based on cost-benefit optimization: A grasslands pilot study. [PDF]

Ecol Appl
Weiskopf SR, Morelli TL, Mozelewski TG, Shiklomanov AN, Lerman SB.   +4 more
europepmc   +1 more source

Development and Validation of Species-Specific KASP and SCAR Markers for the Rapid Identification of the Endangered Orchid <i>Calanthe aristulifera</i>. [PDF]

Plants (Basel)
Hwang JE, Kim S, Park HB, Han SM, Lee Y, Lee CW, Kim YJ.   +6 more
europepmc   +1 more source