Results 111 to 120 of about 5,919 (291)
Frontiers in PsychologyUrban parks are the primary places where urban residents reconnect with natural environments. Numerous studies have shown that natural landscape features benefit human mental health and promote perceived restoration.
Yihe Li, Wenbo Li, Yang Liu
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Restorative policing for the 21st century: historical lessons for future practice
, 2018 Restorative policing has experienced somewhat of a tumultuous journey within the international criminal justice landscape. The practice first emerged in Wagga Wagga, Australia in the early 1990s where its architects drew inspiration from both the New ...
Clamp, Kerry
core
Individuals, communities and the environment: restorative justice as an inclusive structure
, 2021 The paper conceptualises the environment through restorative justice lenses. The analysis departs from the European Landscape Convention and the notion of environment according to the Italian Constitution.
Chiara Perini
core
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Correctional Landscape Studies: Improving the Restorative Potential
, 2020 The United States is the world’s leader in incarceration with 2.2 million people currently in the nation’s prisons and jails. On average, one-third of former offenders will return to prison for re-offence within three years of their release (Bureau of ...
Fairweather, Allyson
core
LandEnhancing the psychological well-being of college students through campus environment design is crucial, particularly in multi-ethnic regions where students’ restoration perceptions may be shaped by their cultural backgrounds. This study investigated the
Chanchan Dong +6 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source