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Using Gene Therapy to Protect and Restore Cartilage
Clinical Orthopaedics and Related Research, 2000Numerous gene products have the potential to help protect cartilage from degradation and to repair cartilage that has become damaged as a result of disease or injury. The genes that encode these products thus may serve as chondroprotective and chondroregenerative medicines.
C H, Evans +5 more
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Restoration of Function by Gene Induction
Science Translational Medicine, 2010Certain thyroid cancer cells can again take up radioactive iodine after selective gene stimulation.
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The Hypogonadal Mouse: Reproductive Functions Restored by Gene Therapy
Science, 1986The hypogonadal ( hpg ) mouse lacks a complete gonadotropin-releasing hormone (GnRH) gene and consequently cannot reproduce. Introduction of an intact GnRH gene into the genome of these mutant mice resulted in complete reversal of the hypogonadal phenotype. Transgenic hpg / hpg
Mason, A. +6 more
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RESTORATIVE GENE THERAPY APPROACHES TO PARKINSON'S DISEASE
Medical Clinics of North America, 1999Perhaps one of the most exciting developments in brain research of the past decade is the advent of genetic intervention in human neurologic disease. Although there are a variety of gene transfer approaches, none of which has been perfected, gene therapy is now science fact and no longer science fiction.
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Restoring sight by gene therapy
Trends in Biotechnology, 2001Gregory M. Acland et al. (Nature Genetics, May issue) report on the first successful use of gene therapy in restoring the sight of dogs blinded by an inherited retinal degenerative disease thus offering hope for humans with a similar condition. The defect was in RPE65, which is a gene associated with the retinal pigment epithelium (RPE).
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Gene Therapy to Restore Hearing
JAMA, 2013ene therapy restored hearing in a mouse model of human hereditary deafness, reports a team led by researchers at the Louisiana State University Health Sciences Center, in New Orleans, and the Rosalind Franklin University of Medicine and Science, in North Chicago ...
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Infertility Treatment: A Nuclear Restorer Gene in Maize
Science, 1996A sterile strain of corn that has been used for making hybrid seed corn carries the Texas male-sterile cytoplasm and does not make pollen. In a report in this issue of Science (see Cui et al ., page 1334 ), cloning of a gene that can restore fertility to these plants ...
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Genes for pollen fertility restoration in sunflowers
Euphytica, 1978Research on 16 sources of pollen fertility restoration revealed that this character was controlled in eight cases by one single dominant gene, in three cases by two complementary genes, in four cases by three complementary genes and in one case by the cumulative action of two nonallelic dominant genes.
A. V. Vrânceanu, F. M. Stoenescu
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Male Sterility and Restorer Genes in Maize
1994Male-sterile plants are those that fail to produce functional pollen grains. In maize, male sterility can result from either nuclear or mitochondrial gene mutation. The former is referred to as genic male sterility and the latter as cytoplasmic male sterility (CMS).
Susan Gabay-Laughnan, John R. Laughnan
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A combined gene and cell therapy approach for restoration of conduction
Heart Rhythm, 2011Abnormal conduction underlies both bradyarrhythmias and re-entrant tachyarrhythmias. However, no practical way exists for restoring or improving conduction in areas of conduction slowing or block.This study sought to test the feasibility of a novel strategy for conduction repair using genetically engineered cells designed to form biological "conducting
Anat, Hofshi +5 more
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