Results 181 to 190 of about 631 (227)

KU80 suppresses endonuclease G activity to preserve genomic integrity

The FEBS Journal, EarlyView.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan, Kwang‐Hyun Park, Hae Ryung Chang, Eunyoung Jung, Myung‐Jin Kim, Jeeyoon Kang, Hyunjo Shim, Eui‐Jeon Woo, Yonghwan Kim   +8 more
wiley   +1 more source

Discovery of a cryptic aminoacidic triad involved in the temperature adaptation of GH1 enzymes

The FEBS Journal, EarlyView.
Cold‐active enzymes retain high catalytic activity at low temperatures but are characterized by thermal instability, a behavior not fully understood. Comparison between a cold‐active GH1 and its mesophilic counterparts highlights the role of a three‐residue motif (W‐M‐F) in conferring structural stability to a mesophilic GH1.
Stefania Digiovanni, Gabriel Oanca, Marco Orlando, Marina Lotti, Johan Åqvist, Marco Mangiagalli   +5 more
wiley   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

A 10-Step Method for Fair Priority-Setting Processes: A Qualitative Case Study from Zanzibar. [PDF]

Health Syst Reform
Mwalim O, Said S, Suleiman S, Bakar F, Khamis H, Mohammed D, Amour Z, Mussa O, Jecha A, Haji AL, Norheim OF, Miljeteig I, Davis A, Hangoma P, Johansson KA.   +14 more
europepmc   +1 more source

Shareholder Activism: Affliction for Incumbent CEOs?

Financial Management, EarlyView.
ABSTRACT We study how shareholder activism shapes CEO careers by distinguishing between two competing hypotheses: discipline and reallocation. Employing a control function approach with expected mutual fund fire sales and purchases as exclusion restrictions, we analyze 3799 US campaigns from 2006 to 2018.
Jana P. Fidrmuc, Jesús Gorrín, Jiaqi Zhao   +2 more
wiley   +1 more source

Reading and relating with Frieda Fromm‐Reichmann and Joanne Greenberg

Critical Quarterly, EarlyView.
Joshua Pugh
wiley   +1 more source

Relationships between chick vocalizations and parental absence in Kentish Plovers

Ibis, EarlyView.
Chick calls within bird species vary greatly, often in relation to whether parents are present. We studied chick calls in a nidifugous shorebird, the Kentish Plover Anarhynchus alexandrinus, in three circumstances—(1) on the nest with parental presence; (2) on the nest with parental absence; and (3) out‐of‐nest with human observer presence—and ...
Dong‐Yun Lee, Edward H. Miller, Ju‐Hyun Lee, Woo‐Yuel Kim, Seung‐Jun Oh, Ha‐Cheol Sung   +5 more
wiley   +1 more source

Janet Malcolm's Self‐Portrait

Critical Quarterly, EarlyView.
Jerome Boyd Maunsell
wiley   +1 more source

The Pen is Mightier Than the Algorithm? A Multilevel Linguistic Comparison of LLM‐ and Human‐Translated Research Article Abstracts

International Journal of Applied Linguistics, EarlyView.
ABSTRACT Translating local research into English as a lingua franca (ELF) connects local scholarship with global readership, but this process remains constrained by language barriers. Large language models (LLMs) offer advanced accessible solutions, but their responsible integration into academic translation requires a deeper understanding of the ...
Yueyue Huang, Yao Yao, Dechao Li
wiley   +1 more source