Results 41 to 50 of about 5,965,661 (287)

A mixed-methods systematic review protocol to examine the use of physical restraint with critically ill adults and strategies for minimizing their use

Systematic Reviews, 2016
Background Critically ill patients frequently experience severe agitation placing them at risk of harm. Physical restraint is common in intensive care units (ICUs) for clinician concerns about safety.
Louise Rose, Craig Dale, Orla M. Smith, Lisa Burry, Glenn Enright, Dean Fergusson, Samir Sinha, Lesley Wiesenfeld, Tasnim Sinuff, Sangeeta Mehta   +9 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Chemical and Physical Restraint of Patients

Procedia - Social and Behavioral Sciences, 2016
AbstractProblem Statement: The physical and chemical restraint of patients, despite being often applied with no real scientific basis, has always been part of nursing practice in caring for the ill people.Research Questions: What is the level of knowledge over in nursing about physically and chemically restraining?Purpose of the Study: Evaluate the ...
Cunha, Madalena, André, Susana, Bica, Isabel, Ribeiro, Olivério, Dias, António, Andrade, Ana   +5 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Physical restraint use.

, 2015
NRCT, non-randomized controlled trial; RCT, randomized controlled trial; CG, control group; IG, intervention group; wks, weeks; res, residents.Physical restraint use.
Margaret MacAndrew (825215), Elizabeth Beattie (825216), Yun-Hee Jeon (825214), Belinda Goodenough (825213), Jennifer Fletcher (825212), Lee-Fay Low (825211), Christopher Etherton-Beer (398694)   +6 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Touch, physical restraint and therapeutic containment in residential child care [PDF]

, 2012
The relationship between touch and physical restraint in residential child care is not well understood. Theories of therapeutic containment offer insight into the practice of physical restraint, the place of touch in residential child care practice and ...
Steckley, Laura
core   +1 more source

Nurses’ Knowledge, Attitude, and Influencing Factors regarding Physical Restraint Use in the Intensive Care Unit: A Multicenter Cross-Sectional Study

Critical Care Research and Practice, 2020
Background. Physical restraint is a common practice in the intensive care units which often result in frequent skin laceration at restraint site, limb edema, restricted circulation, and worsening of agitation that may even end in death.
Tilahun Kassew, Ambaye Dejen Tilahun, Bikis Liyew   +2 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source