Results 31 to 40 of about 5,213,227 (370)

The randomization-induced risk of a trial failing to attain its target power: assessment and mitigation

open access: yesTrials, 2019
Health researchers are familiar with the concept of trial power, a number that prior to the start of a trial is intended to describe the probability that the results of the trial will correctly conclude that the intervention has an effect.
Hubert Wong   +2 more
doaj   +1 more source

Discrete Optimization for Interpretable Study Populations and Randomization Inference in an Observational Study of Severe Sepsis Mortality [PDF]

open access: yes, 2015
Motivated by an observational study of the effect of hospital ward versus intensive care unit admission on severe sepsis mortality, we develop methods to address two common problems in observational studies: (1) when there is a lack of covariate overlap ...
Fogarty, Colin B.   +3 more
core   +2 more sources

Inverse probability weighting to estimate causal effect of a singular phase in a multiphase randomized clinical trial for multiple myeloma

open access: yesBMC Medical Research Methodology, 2016
Background Randomization procedure in randomized controlled trials (RCTs) permits an unbiased estimation of causal effects. However, in clinical practice, differential compliance between arms may cause a strong violation of randomization balance and ...
Annalisa Pezzi   +4 more
doaj   +1 more source

Sequential monitoring with conditional randomization tests

open access: yes, 2012
Sequential monitoring in clinical trials is often employed to allow for early stopping and other interim decisions, while maintaining the type I error rate.
Plamadeala, Victoria   +1 more
core   +1 more source

Impact of phenylalanine on cognitive, cerebral, and neurometabolic parameters in adult patients with phenylketonuria (the PICO study): a randomized, placebo-controlled, crossover, noninferiority trial

open access: yesTrials, 2020
Background The population of adult patients with early-treated phenylketonuria (PKU) following newborn screening is growing substantially. The ideal target range of blood phenylalanine (Phe) levels in adults outside pregnancy is a matter of debate ...
Roman Trepp   +8 more
doaj   +1 more source

Efficient generation of random derangements with the expected distribution of cycle lengths

open access: yes, 2020
We show how to generate random derangements efficiently by two different techniques: random restricted transpositions and sequential importance sampling.
Mendonça, J. R. G.
core   +1 more source

Pilot randomized controlled trial of restricted versus liberal crystalloid fluid management in pediatric post-operative and trauma patients

open access: yesPilot and Feasibility Studies, 2023
Background Intravenous (IV) fluid therapy is essential in the treatment of critically ill pediatric surgery and trauma patients. Recent studies have suggested that aggressive fluids may be detrimental to patients.
Vincent P. Duron   +7 more
doaj   +1 more source

Minimal cost multifactor experiments for agricultural research involving hard-to-change factors

open access: yesThe Indian Journal of Agricultural Sciences, 2021
Multifactor experiments are very common in agricultural research. Randomizing run orders in multifactor experiments often witness in large number of factorwise level changes which will increase the cost and time of the experiments.
BIJOY CHANDA   +8 more
doaj   +1 more source

Information transport and limits of optical imaging in the highly diffusive regime

open access: yesPhysical Review Research, 2023
Imaging in the highly diffusive regime lies at the heart of various optical medical imaging technologies and other applications such as imaging through fog.
Jack Radford, Daniele Faccio
doaj   +1 more source

Rerandomization to improve covariate balance in experiments

open access: yes, 2012
Randomized experiments are the "gold standard" for estimating causal effects, yet often in practice, chance imbalances exist in covariate distributions between treatment groups.
Morgan, Kari Lock, Rubin, Donald B.
core   +1 more source

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