Results 81 to 90 of about 5,213,227 (370)

Key Distillation and the Secret-Bit Fraction

open access: yes, 2008
We consider distillation of secret bits from partially secret noisy correlations P_ABE, shared between two honest parties and an eavesdropper. The most studied distillation scenario consists of joint operations on a large number of copies of the ...
Jones, Nick S., Masanes, Lluis
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Diabetes Mellitus and Risk of Future Stroke: Evidence From CHARLS and Mendelian Randomization Analyses

open access: yesBrain and Behavior
Objectives: This study leveraged the China Health and Retirement Longitudinal Study (CHARLS) to explore the association between diabetes and stroke in middle‐aged and older adults in East Asia and assess the causality of this relationship using Mendelian
Zetai Bai   +4 more
doaj   +1 more source

On Nearly Balanced Designs for Sensory Trials [PDF]

open access: yes
In sensory experiments, often designs are used that are balanced for carryover effects. It is hoped that this controls for possible carryover effects, like, e.g., a lingering taste of the products. Proper randomization is essential to guarantee the usual
Kunert, Joachim, Sailer, Oliver
core  

Randomized protocols for asynchronous consensus

open access: yes, 2002
The famous Fischer, Lynch, and Paterson impossibility proof shows that it is impossible to solve the consensus problem in a natural model of an asynchronous distributed system if even a single process can fail.
Aspnes, James
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

cvcrand: A Package for Covariate-constrained Randomization and the Clustered Permutation Test for Cluster Randomized Trials

open access: yesThe R Journal, 2019
The cluster randomized trial (CRT) is a randomized controlled trial in which randomization is conducted at the cluster level (e.g. school or hospital) and outcomes are measured for each individual within a cluster. Often, the number of clusters available
Hengshi Yu, Fan Li, J. Gallis, E. Turner
semanticscholar   +1 more source

Mean-Variance Optimization in Markov Decision Processes [PDF]

open access: yes, 2011
We consider finite horizon Markov decision processes under performance measures that involve both the mean and the variance of the cumulative reward. We show that either randomized or history-based policies can improve performance.
Mannor, Shie, Tsitsiklis, John
core   +3 more sources

Uncertainty Relations and Sparse Signal Recovery for Pairs of General Signal Sets

open access: yes, 2011
We present an uncertainty relation for the representation of signals in two different general (possibly redundant or incomplete) signal sets. This uncertainty relation is relevant for the analysis of signals containing two distinct features each of which
Bölcskei, Helmut   +2 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

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