Results 101 to 110 of about 192,968 (237)
Advanced Science, EarlyView.The apple susceptibility‐related LRR‐RLK MdRLKT21 competitively binds to fungal sRNA effectors and subsequently activates defenses by salvaging the expression of MdRLKT1 and MdRLKT2 and thereby releasing the resistance protein MdRFP1. These findings provide new insights into the molecular mechanism by which plants counteract pathogen‐secreted sRNA ...
Mingliang Lei +7 more
wiley +1 more source
Aging and the Spectral Properties of Brain Hemodynamics
Advanced Science, EarlyView.As the brain ages, its metabolic demands decline—but not uniformly. Here, spectral slope flattening of resting‐state fMRI signals is proposed as a potential biomarker of pathologic brain aging. A subset of older adults diverges from youthful spectral and metabolic patterns, with changes linked to frontal white matter pathology and regional loss of ...
Ki Yun Park +9 more
wiley +1 more source
Advanced Science, EarlyView.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
Advanced Science, EarlyView.The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan +13 more
wiley +1 more source
Optimal Labor-Market Policy in Recessions [PDF]
We examine the optimal labor market-policy mix over the business cycle. In a search and matching model with risk-averse workers, endogenous hiring and separation, and unobservable search effort we first show how to decentralize the constrained-efficient ...
Jung, Philip, Kuester, Keith
core
Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy
Advanced Science, EarlyView.This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou +14 more
wiley +1 more source
Right ventricular dysfunction: a key predictor of post-intubation hypotension in the emergency department. [PDF]
Int J Emerg MedPrakash P +5 more
europepmc +1 more source
Numerical Study of Restricted Shock Separation in a Compressed Truncated Perfect Nozzle
Numerical Study of Restricted Shock Separation in a Compressed Truncated Perfect Nozzle資料番号 ...
openaire
Cut‐Enabled Mechanical Metamaterials for Multimodal and Reprogrammable Static Nonreciprocity
Advanced Science, EarlyView.Cut‐enabled mechanical metamaterials are designed to overcome the challenge of obtaining multiple and reprogrammable static nonreciprocal modes in a single microstructural topology. It offers a pathway to synthesize multiple nonreciprocal modes and control the nonreciprocal responses, enhancing the functionality of metamaterials.
Jinhao Zhang +8 more
wiley +1 more source
Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis
Advanced Science, EarlyView.Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves +17 more
wiley +1 more source