Results 111 to 120 of about 198,522 (234)

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

Role of p62 nuclear condensates in regulating ubiquitin-mediated proteasomal degradation. [PDF]

Essays Biochem
Lulu-Shimron C, Ciechanover A, Cohen-Kaplan V.   +2 more
europepmc   +1 more source

Boron Nitride Reinforced Supramolecular Gels Nano‐Assembled with Fungicides toward Soil‐Borne Fungal Disease Management

Advanced Science, EarlyView.
This work demonstrates of 2D material‐mediated stimuli‐responsive transport in soft matter systems, pioneers a new class of nano‐bridged carriers with mechanically strengthening and programmable permeability characteristics designed to overcome persistent barriers in soil‐borne disease management.
Li Hao, Jialin Zeng, Weixian Qiu, Jinhui Wang, Xiaoshan Huang, Jiachun Wu, Zhensong Weng, Ziting Yin, Hongjun Zhou, Xinhua Zhou   +9 more
wiley   +1 more source

Mortality effect of higher versus lower blood pressure targets in vasodilatory shock: an updated systematic review and meta-analysis. [PDF]

Crit Care
Mendes H, King J, Kumar N, Deshpande K, Panwar R, van Haren FMP.   +5 more
europepmc   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Transcatheter Edge-to-Edge Mitral Valve Repair for Severe Regurgitation in Cardiogenic Shock: A Comprehensive Review. [PDF]

J Cardiovasc Dev Dis
Biswas M, Katz WE, Suffoletto M, Rhinehart Z, Smith AC, Fowler J, Sade LE.   +6 more
europepmc   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Electromagnetic Field Stimulation Effects on Intrinsically Disordered Proteins and Their Role in Aging and Neurodegeneration. [PDF]

J Biomed Sci Eng
Perez FP, Bandeira J, Morisaki J, Kanakri H, Rizkalla M.   +4 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Prognostic Value of Different Iron Status Definitions in Congestive Heart Failure: A Retrospective MIMIC-IV Analysis of Risk Stratification and Mortality. [PDF]

J Clin Med
Hourani AZ, Sürmeli AD, Devarapalli SK.
europepmc   +1 more source