Results 151 to 160 of about 192,968 (237)

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold

Advanced Science, EarlyView.
To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato, June Ho Hwang, Manolo U. Rios, Nicole E. Familiari, Michael K. Rosen, Jeffrey B. Woodruff   +5 more
wiley   +1 more source

Biomolecular phase separation in tumorigenesis: from aberrant condensates to therapeutic vulnerabilities. [PDF]

Mol Cancer
Hu L, Huang Z, Liu Z, Zhang Y.
europepmc   +1 more source

Alkaline–Acid Intestine Environment Controlled by A Carbonic Anhydrase Gene Influences Synthesis of Sex Pheromone by Symbionts

Advanced Science, EarlyView.
A model proposing that elevated rectal expression of CAh1 in males alkalinizes the environment to regulate Bacillus production of a male‐specific sex pheromone. Abstract The intricate interplay between animals and their intestinal microbes is pivotal in shaping various aspects of animal biology.
Shiyu Gui, Lexin Xie, Zhenghao Wang, Yan Chen, Yi Xiao, Ziyun Lin, Jingxiang Chen, Yongyue Lu, Laurent Keller, Daifeng Cheng   +9 more
wiley   +1 more source

Simulation Models for Exploring Magnetic Reconnection. [PDF]

Space Sci Rev
Shay M, Adhikari S, Beesho N, Birn J, Büchner J, Cassak P, Chen LJ, Chen Y, Cozzani G, Drake J, Guo F, Hesse M, Jain N, Pfau-Kempf Y, Lin Y, Liu YH, Oka M, Omelchenko Y, Palmroth M, Pezzi O, Reiff PH, Swisdak M, Toffoletto F, Toth G, Wolf RA.   +24 more
europepmc   +1 more source

Probing the Dynamics Process of High‐Entropy Alloy Catalysts: Fundamentals, Synthesis, and In Situ TEM Insights

Advanced Science, EarlyView.
Schematic illustration of the basic properties, machine learning synthesis strategy, and formation under in situ TEM of HEAs. Abstract Catalysts play a crucial role in advancing green and clean energy technologies for a sustainable future. Among the various catalysts reported, high‐entropy alloys (HEAs) stand out due to their superior stability and ...
Haider Ali, Yan Xu, Xiao Han, Yue Lin
wiley   +1 more source

ChronoSynthNet: a dual-task deep learning model development and validation study for predicting real-time norepinephrine dosage and the early detection of hypotension in patients with septic shock. [PDF]

Cardiovasc Diagn Ther
Jiang Z, Zhang S, Yuan Y, Wang J, Hu Z.
europepmc   +1 more source

Single‐Cell Nucleus Extraction with Cellular Indexing

Advanced Science, EarlyView.
VacTrap is a multilayer, high‐throughput microfluidic system that isolates and spatially indexes single nuclei from hundreds of cells within minutes. Using dissolvable hydrogel trapdoors triggered by chemical and vacuum actuation, VacTrap synchronously transfers nuclei while preserving spatial links to parent cells.
Trinh Lam, Ana Esmeralda Gomez Martinez, Alison Su, Anna Fomitcheva‐Khartchenko, Xin Wang, Md Nazibul Islam, Paul Lum, Amy Elizabeth Herr   +7 more
wiley   +1 more source

Serum proteomes and their prognostic values in sepsis patients admitted to a medical intensive care unit: a single-center study using SWATH-MS proteomics. [PDF]

Ann Intensive Care
Lee SY, Ahn JH, Hong SB, Hyun DG, Lim CM, Kim K, Huh JW.   +6 more
europepmc   +1 more source

Enhanced Protein Synthesis and Hippocampus‐Dependent Memory via Inhibition of YTHDF2‐Mediated m6A mRNA Degradation

Advanced Science, EarlyView.
YTHDF2‐mediated m6A mRNA decay critically regulates learning and memory. Its forebrain‐specific knockout in mice impedes degradation of m6A‐modified mRNAs, enhancing hippocampal synaptic transmission, protein synthesis, and memory. Conversely, hippocampal YTHDF2 reintroduction or SEMA4B reduction reverses this enhancement, while its overexpression ...
Kuan Li, Chen Guo, Xiaoli Wu, Cuiting Wu, Songfen Wu, Si Su, Min Wu, Xidan Zhou, Si Li, Yihui Cui, Tao Zhou   +10 more
wiley   +1 more source

Nucleolar Organization in Response to Transcriptional Stress. [PDF]

Cancer Sci
Imamura R, Yasuhara T.
europepmc   +1 more source