Results 21 to 30 of about 192,968 (237)
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Transient Three-Dimensional Startup Side Load Analysis of a Regeneratively Cooled Nozzle [PDF]
, 2008 The objective of this effort is to develop a computational methodology to capture the startup side load physics and to anchor the computed aerodynamic side loads with the available data from a regeneratively cooled, high-aspect-ratio nozzle, hot-fired at
Wang, Ten-See
core +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Whistler mode waves upstream of Saturn [PDF]
, 2016 Whistler-mode waves are generated within and can propagate upstream of collisionless shocks. They are known to play a role in electron thermodynamics/acceleration and, under certain conditions, are markedly observed as wave trains preceding the shock ...
Dougherty, Michele K +5 more
core +3 more sources
Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó +17 more
wiley +1 more source
Design and fabrication of a centrifugally driven microfluidic disk for fully integrated metabolic assays on whole blood [PDF]
, 2006 For the first time, we present a novel and fully integrated centrifugal microfluidic “ lab-on-a-disk” for rapid metabolic assays in human whole blood.
Brenner, T. +5 more
core +2 more sources
Advanced Biology, EarlyView.The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li +10 more
wiley +1 more source
Transient Three-Dimensional Side Load Analysis of a Film Cooled Nozzle [PDF]
, 2008 Transient three-dimensional numerical investigations on the side load physics for an engine encompassing a film cooled nozzle extension and a regeneratively cooled thrust chamber, were performed.
Guidos, Mike, Wang, Ten-See
core +1 more source
Black Hole Formation in Fallback Supernova and the Spins of LIGO Sources
, 2018 Here we investigate within the context of field binary progenitors how the the spin of LIGO sources vary when the helium star-descendent black hole (BH) is formed in a failed supernova (SN) explosion rather than by direct collapse.
Batta, Aldo +2 more
core +1 more source
Advanced Engineering Materials, EarlyView.This review explores wafer bonding technologies, covering wafer preparation, activation methods, and bonding mechanisms. It compares direct and indirect bonding, highlights recent advancements and future trends, and examines applications in 3D integration and packaging.
Abdul Ahad Khan +5 more
wiley +1 more source