Results 101 to 110 of about 1,050,756 (279)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Affine modifications and affine hypersurfaces with a very transitive automorphism group

, 1998
We study a kind of modification of an affine domain which produces another affine domain. First appeared in passing in the basic paper of O. Zariski (1942), it was further considered by E.D. Davis (1967).
?. ?. ???????, ?. ??????????, ?. ??????????, A. Dold, A. Micali, A. Sathaye, C. P. Ramanujam, D. Eisenbud, D. Wright, D. Wright, E. Brieskorn, E. D. Davis, F. Forstneri?, G. E. Bredon, H. Flenner, H. Hironaka, H. W. E. Jung, J. Milnor, J. Milnor, J. Milnor, J. Winkelmann, J.-P. Rosay, J.-P. Serre, L. Makar-Limanov, L. Makar-Limanov, M. Gromov, M. Koras, M. Suzuki, O. Zariski, P. Russell, P. Russell, R. Hartshorn, R. Rentschler, S. Kaliman, S. Kaliman, S. Kaliman, S. Kaliman, S. Kaliman, S. S. Abhyankar, T. Fujita, T. tom Dieck, V. Srinivas, W. Fulton, W. Kulk van der, Z. Jelonek   +44 more
core   +4 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Antisense RNA associated with biological regulation of a restriction–modification system

Nucleic Acids Research, 2011
Restriction–modification systems consist of a modification enzyme that methylates a specific DNA sequence and a restriction endonuclease that cleaves DNA lacking this epigenetic signature.
Iwona Mruk, Yaoping Liu, Liying Ge, I. Kobayashi   +3 more
semanticscholar   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Quantifying Privacy: A Novel Entropy-Based Measure of Disclosure Risk

, 2014
It is well recognised that data mining and statistical analysis pose a serious treat to privacy. This is true for financial, medical, criminal and marketing research.
A Oganian, C Dwork, CCM Fung, CJ Skinner, D Lambert, DE Denning, F Al-Saggaf, GT Duncan, JR Griggs, L Brankovic, L Brankovic, L Brankovic, L Brankovic, L Brankovic, L Brankovic, L Brankovic, L Brankovic, L Sankar, L Willenborg, M Trottini, N Lopez, N López, NR Adam, P Horak, P Tendick, R Ahlswede, S Fletcher, S Morris, T King, V Estivill-Castro, V Estivill-Castro, WA Fuller, WE Winkler, WE Yancey, Y Al-Saggaf   +34 more
core   +1 more source

Dietary alterations modulate the microRNA 29/30 and IGF-1/AKT signaling axis in breast Cancer liver metastasis. [PDF]

, 2020
Background: Metastatic cancer is incurable and understanding the molecular underpinnings is crucial to improving survival for our patients. The IGF-1/Akt signaling pathway is often impaired in cancer leading to its progression and metastases.
Camphausen, Kevin, DeAngelis, Tiziana, Saleh, Anthony, Savage, Jason E., Shastri, Anuradha A., Simone, Nicole L.   +5 more
core   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source