Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
MicroorganismsMycobacterium tuberculosis (Mtb), as a typical intracellular pathogen, possesses several putative restriction–modification (R-M) systems, which restrict exogenous DNA’s entry, such as bacterial phage infection.
Tong Liu +8 more
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Improved genetic transformation by disarmament of type II Restriction-Modification system in Streptococcus zooepidemicus. [PDF]
3 Biotech, 2022 Gao W, Xie Y, Zuo M, Zhang G, Liu H.
europepmc +1 more source
The Role of DNA Restriction-Modification Systems in the Biology of Bacillus anthracis [PDF]
, 2016 Ramakrishnan Sitaraman
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Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
A mobile restriction-modification system provides phage defence and resolves an epigenetic conflict with an antagonistic endonuclease. [PDF]
Nucleic Acids Res, 2022 Birkholz N +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
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Identification of three different plasmid-encoded restriction/modification systems in Streptococcus lactis subsp. cremoris W56 [PDF]
, 1989 Jytte Josephsen, Finn K. Vogensen
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YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Gene structure and expression of theMbolrestriction − modification system [PDF]
, 1993 Takashi Ueno +4 more
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