Results 181 to 190 of about 179,539 (265)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

The Patchy Distribution of Restriction⁻Modification System Genes and the Conservation of Orphan Methyltransferases in Halobacteria. [PDF]

Genes (Basel), 2019
Fullmer MS, Ouellette M, Louyakis AS, Papke RT, Gogarten JP.   +4 more
europepmc   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Effect of restriction-modification systems on transfer of foreign DNA into Lactococcus lactis subsp. lactis [PDF]

, 1989
Philippe Langella
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The streptococcal phase-variable type I restriction modification system SsuCC20p dictates the methylome of Streptococcus suis impacting the transcriptome and virulence in a zebrafish larvae infection model. [PDF]

mBio
Roodsant TJ, van der Putten B, Brizuela J, Coolen JPM, Baltussen TJH, Schipper K, Pannekoek Y, van der Ark KCH, Schultsz C.   +8 more
europepmc   +1 more source

Systematic Analysis of REBASE Identifies Numerous Type I Restriction-Modification Systems with Duplicated, Distinct hsdS Specificity Genes That Can Switch System Specificity by Recombination

, 2020
John M. Atack, Chengying Guo, Thomas Litfin, Long Yang, P. J. Blackall, Yaoqi Zhou, Michael P. Jennings   +6 more
openalex   +1 more source

7-Deazaguanine modifications protect phage DNA from host restriction systems [PDF]

, 2019
Geoffrey Hutinet, Witold Kot, Cui Liang, Roman Hillebrand, Seetharamsingh Balamkundu, Shanmugavel Gnanakalai, Ramesh Neelakandan, Alexander Byth Carstens, Chuan Fa Lui, Denise M. Tremblay, Deborah Jacobs‐Sera, Mandana Sassanfar, Yan‐Jiun Lee, Peter Weigele, Sylvain Moineau, Graham F. Hatfull, Peter C. Dedon, Lars Hestbjerg Hansen, Valérie de Crécy‐Lagard   +18 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Markerless deletion of the putative type I and III restriction-modification systems in the cellulolytic bacterium Clostridium cellulovorans using a codBA-based counterselection technique

Luciana Almeida, Aline I. Schöllkopf, Holger Edelmann, Armin Ehrenreich, Wolfgang Liebl   +4 more
openalex   +1 more source